Abx pharm pt.2 - Exam 1A Flashcards
what class are Gentamycin, Amikacin and Tobramycin
Aminoglycosides
aminoglycosides MOA
Binds to the bacterial ribosomes and prevents protein synthesis
Gentamycin, Amikacin and Tobramycin indications
UTI/pyelonephritis, gynecological infections, peritonitis, endocarditis, PNA, osteomyelitis (DM related infections)
COMPLICATED INFECTIONS
Gentamycin, Amikacin and Tobramycin SE
Nephrotoxicity (reversible)
Ototoxicity (nonreversible)
Gentamycin, Amikacin and Tobramycin nursing consideratiosn
Peak & troughs level drawn
Dose by renal function
Often used with beta-lactam abx or vancomycin
works well on gram -
Gentamycin SE
confusion, depression, disorientation, numbness, & tingling (CNS)
cochlear damage
Gentamycin nursing considerations
Try to not give w/ a neuromuscular blockage (paralytic) d/t resp distress (myasthenia gravis)
what class is clindamycin
lincosamides
clindamycin indication
Chronic bone infections, GU infections, intraabdominal infections, anaerobic pneumonia, septicemia, serious skin infections, prophylaxis for endocarditis
clindamycin SE
Very toxic
Can cause deadly pseudomembranous colitis (complication of diarrhea causing bloody stools, GI distress, and diarrhea -> c.diff)
clindamycin nursing considerations
All Enterobacter bacteria (VRE, CRE) are resistant to clindamycin
Monitor for neuromuscular blockade meds
Peak & trough levels
if pt develops c.diff, get off med
clindamycin MOA
Binds to ribosomes and inhibits protein synthesis
what class are Erythromycin and Azithromycin (Z-pack)
macrolides
macrolides MOA
Inhibit protein synthesis by binding to ribosomes
(bacteriostatic)
Erythromycin and Azithromycin indications
Various infections of upper and lower respiratory infections, skin infections, soft tissue infections, STIs (esp gonorrhea)
Legionnaire’s, listeria, mycoplasma pneumonia
Erythromycin and Azithromycin SE
“yuck drugs” GI side effect profile is intense
Z-pack has less GI upset