non HIV & HIV pharm - Exam 1A Flashcards
Acyclovir MOA
1)interferes with viral nucleic acid synthesis, its regulation or both (DNA & RNA)
2)prevents virus from binding to cells so virus cannot get into cells preventing replication
3)stimulates the body’s immune system to kill the virus
what class is Acyclovir
Anti-viral (non-HIV)
Acyclovir indications
HSV 1&2
Herpes zoster
Chickenpox/varicella
Acyclovir SE
GI distress
Renal impairment
Seizures
ITP (idiopathic thrombocytopenia)
Tissue necrosis w/ IV route
Acyclovir nursing considerations
Not a cure
Monitor pt with low platelet counts
what class is Oseltamivir (tamiflu)
Anti-viral (non-HIV)
Oseltamivir (tamiflu) MOA
Inhibit neuraminidases in influenza viruses
Oseltamivir (tamiflu) indications
Prophylaxis and to treat active flu disease (48hr of sx onset)
Swine flu
Oseltamivir (tamiflu) SE
N/v
Seizures
Renal impairment
Oseltamivir (tamiflu) nursing considerations
Most active against flu A
Has to be started before or within 48 hrs of symptom onset
Only given to elderly & immunocompromised after known exposure
what class is Ganciclovir
Anti-viral (non-HIV)
Ganciclovir MOA
Inhibits viral DNA polymerases resulting in chain termination
Ganciclovir indication
Cytomegalovirus (CMBV -> immuno comp pts)
Ganciclovir SE
Very toxic
Nephrotoxic if given with other nephrotoxic drugs
Ganciclovir nursing considerations
BBW: hematologic toxicity, fertility impairment, fetal toxicity, carcinogenesis
Don’t give with imipenem cilastatin bc seizure potential
Do not crush or split d/t skin irritation
