musculoskeletal - pharm E4 Flashcards
what class is Aldendronate
biphosphates
biphosphates MOA
Binds permanently to surface of bones to inhibit osteoclast activity
Aldendronate indication
osteoporosis
Aldendronate SE
N/V/D
Esophageal ulceration
Aldendronate nursing considerations
do not lay down after taking d/t ulceration risk
do not take calcium (or other food/drinks) with this bc will lower bioavailability)
given 1x/wk
what class is Raloxifene
Selective estrogen receptor modulators (SERMs)
Selective estrogen receptor modulators (SERMs) MOA
Mimics estrogen by increasing bone density, inhibits bone resorption
Raloxifene indications
Preventing or treating postmenopausal osteoporosis
Raloxifene SE
Hot flashes
Leg problems
Stroke risk
Raloxifene nursing considerations
Safer than a hormone replacement, less affective the biphos
BBW: stroke risk
Need to take adequate calcium & vit D for this to work
Discontinue at least 72 hrs before planned procedures
Do not smoke or drink
Do not take if pregnant
what class is Calcitonin Salmon
calcitonin
Calcitonin Salmon MOA
Inhibits bone removal by osteoclasts
Calcitonin Salmon indication
Treatment of osteoporosis
Calcitonin Salmon SE
Nasal irritation
Calcitonin Salmon nursing consideration
Have to take for 5 years to see long term benefit
Slows done bone loss and increases spinal bone density
Given intranasal
what class is Methotrexate
DMARD ; antineoplastic, anti-rheumatic
Methotrexate MOA
Immunosuppressive -> interferes w/ folic acid metabolism
Methotrexate indication
RA
Methotrexate SE
GI
Bone marrow suppression
Shortened life expectancy
Methotrexate nursing consideration
Need folic acid replacement
1x/wk or deadly
Hepatotoxic -> monitor liver enzymes
Monitor RBCs & WBCs
11 BBW
-no alcohol
-teratogenic (need BC)
-high infection risk
-liver & kidney disease
-aplastic anemia w/ NSAID use
what class is Hydroxychloroquine
DMARD; antimalarial, anti rheumatic