Abx pharm pt.1 - Exam 1A Flashcards
MOA of all “cillins”
disrupt the synthesis of the cell wall
penicillin indications
Gonorrhea, peritonitis, UTI, pneumonia & resp infections, septicemia, meningitis
penicillin SE
Utricaria (rash)
Pruritis (itching)
Angioedema
penicillin nursing considerations
Rash very common in kid
Person might not have true allergy but rashes can indicate anaphylaxis
Interact w/ NSAIDS, Oral Contraceptives & Warfarin
what class are PCN G & PCN V
natural penicillins
indications for PCN G & V
Gonorrhea, peritonitis, UTI, pneumonia & resp infections, septicemia, meningitis
PCN G & V SE
rash
PCN G & V nursing considerations
Works on gram +&-, anaerobic, and spirochetes
½ life 30 mins expect w/ kidney dysfunction
Least toxic
what class is nafcillin
Penicillinase Resistant Penicillins
nafcillin indications
Gonorrhea, peritonitis, UTI, pneumonia & resp infections, septicemia, meningitis, staph infection
nafcillin SE
rash
nafcillin nursing considerations
IV only
Resist breakdown by the penicillanse enzyme that is commonly seen in a staph infection
what class are amoxicillin and ampicillin
aminopenicillins
amoxicillin and ampicillin indications
Gonorrhea, peritonitis, UTI, pneumonia & resp infections, septicemia, meningitis
ampicillin SE
diarrhea & rash
ampicillin nursing considerations
renal sensitive
using less d/t drug resistance but 1st broad spectrum drug
usually given with a beta lactum abx (Unasyn)
amoxicillin nursing considerations
less SE & only PO
works better on against gram - then other penicillins
commonly for for ears, nose, throat, genitourinary & skin infections
what class is piperacillin
Extended Spectrum Penicillins
piperacillin indications
Gonorrhea, peritonitis, UTI, pneumonia & resp infections, septicemia, meningitis
piperacillin SE
rash
hard on kidney’s bc it is a board spectrum abx
affects platelet function
piperacillin nursing considerations
Always given with a beta lactamase inhibitor (Zosyn)
Very good for pseudomonal infections (get through water & causes res distress, HA, pus fill sacs on skin, disorientation)
Broadest spectrum (pull peak & trough)
what class is cephalosporin
cephalosporins
cephalosporins (general & all the generations) MOA
Disrupt the synthesis of the cell wall (active autolysis)
cephalosporin indications
STDs, peritonitis, UTI, pneumonia & resp infections, septicemia, meningitis
cephalosporin SE
Mild diarrhea
Abdominal cramps
Rash
Pruritis
Redness
edema
cephalosporin nursing considerations
safe for pregnancy (category B)
poor oral absorption
low toxicity
avoid if PCN anaphylaxis