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ABSN > Endocrine pharm - E3 > Flashcards

Endocrine pharm - E3 Flashcards

1
Q

what class is Aminoglutethimide

A

Adrenal corticosteroid inhibitor

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2
Q

Adrenal corticosteroid inhibitor MOA

A

Blocks synthesis of all adrenal steroids

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3
Q

Aminoglutethimide indications

A

Temporary therapy to decrease cortisol production

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4
Q

Aminoglutethimide SE

A

Drowsiness
Nausea
Anorexia
Rash

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5
Q

Aminoglutethimide nursing considerations

A

Usually do not use longer than 3 months -> does not treat anything just manages

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6
Q

what class is ketoconazole

A

anti fungal

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7
Q

anti fungal MOA

A

Antifungal that also inhibits glucocorticoid synthesis

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8
Q

ketoconazole indication

A

Adjunct therapy to surgery or radiation for cushing syndrome

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9
Q

ketoconazole nursing consideration

A

Can become very toxic to the liver-> do not drink

Cannot take during pregnancy bc can cause fetal thyroid damage

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10
Q

ketoconazole SE

A

severe liver damage

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11
Q

what class is Phenoxybenzamine HCL

A

alpha blockers

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12
Q

alpha blockers MOA

A

Long lasting, irreversible blockage of alpha adrenergic receptors

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13
Q

Phenoxybenzamine HCL indication

A

Pheochromocytoma

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14
Q

Phenoxybenzamine HCL SE

A

Lowers BP
Orthostatic hypotension
Reflex tachycardia
Nasal congestion
Sexual side effects in men

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15
Q

Phenoxybenzamine HCL nursing considerations

A

smooth muscle relaxer so lower BP

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16
Q

what class is Demeclocycline

A

Tetracycline broad spectrum antibiotic

17
Q

Tetracycline broad spectrum abx MOA

A

Interferes w/ renal response to ADH

18
Q

Demeclocycline indications

A

Treatment of chronic SIADH

19
Q

Demeclocycline SE

A

Photosensitivity
Teeth staining
Nephrotoxic

20
Q

Demeclocycline nursing considerations

A

Not first line treatment, try to restrict fluids firsts
can also give loop diuretics but only if Na is >125

21
Q

what class is Desmopressin [DDAVP]

A

Antidiuretic hormone

22
Q

Antidiuretic hormone MOA

A

Synthetic ADH replacement -> gives anti diuretic effects

23
Q

Desmopressin [DDAVP] indications

A

Treatment for neurogenic DI

24
Q

Desmopressin [DDAVP] SE

A

Small dose: none
Nasal spray: nasal irritation
Large doses: hyponatremia, water intoxication

25
Q

Desmopressin [DDAVP] nursing considerations

A

Cannot be used for nephrogenic DI bc ADH doesn’t have an effect on the kidneys

26
Q

what class is Levothyroxine

A

T4 synthetic thyroid hormone

27
Q

T4 synthetic thyroid hormone MOA

A

Converts to T3 in the body

28
Q

Levothyroxine indication

A

Treatment for hypothyroidism

29
Q

Levothyroxine SE

A

If dose too high: hyperthyroid symptom

If dose too low: hypothyroid symptom

30
Q

Levothyroxine nursing considerations

A

long half life -> stay steady between doses but takes a month for effects to kick in

take on an empty stomach

increases risk of bleeding if pt is on warfarin

taken for life

31
Q

drug therapy for Addison’s Disease

A

life long corticosteroid replacement
-all get glucocorticoid (drug of choice is hydrocortisone bc has min + glu but could be prednisone or dexamethasone paired w/ fludrocortisone)
give as small of dose as possible

32
Q

when should a person w/ Addison’s take their steroids

A

take all at bedtime because that is when our body naturally produces cortisol (but some dr divide the dose to 2/3 in the morning & 1/3 at night)

33
Q

when a person w/ Addison’s disease is in a stressed state, what do they need to do with their medications

A

must increase glucocorticoid dose -> failure to do so can be fatal bc a healthy body naturally increases glucocorticoid in response to stress so these people need to do the same (ex: illness or surgery)
3x3 rule

34
Q

to avoid an addisonian crisis, what should you never do

A

never abruptly stop drug therapy

35
Q

main teaching point for people with Addison’s disease

A

must carry extra meds on them at all times and they have to have an injectable preparation plus an oral preparation & they should wear a medical bracelet

ABSN (145 decks)

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