POM-P Switches - Orlistat

Question 1

What is the indication of Orlistat? (2)

Answer 1

Weight loss in adults (18+) who are overweight or obese (BMI > 28kg/m2.
Check BMI before supply.

Question 2

Explain the effect of Orlistat. (1)

Answer 2

Blocks absorption of 25% dietary fat.

Question 3

What is the dose of Orlistat? (1)

Answer 3

60mg TDS immediately before, during or up to 1 hr after each meal. If no meal, no fat miss tablet.
Should be with a low fat diet (aids weight loss and minimises GI s/e.)

Question 4

What is the max tx duration of Orlistat? (1)

Answer 4

6 months

Question 5

What is the referral symptoms for Orlistat? (7)

Answer 5

< 18 yrs / BMI < 28kg/m2
No weight loss after 12 weeks of tx.
Taking > 6 months.
Pregnant/breastfeeding
Rx: Amiodarone, Levothyroxine, Antiepileptics, Ciclosporin, Warfarin, Anticoagulants, Anti-diabetics,

Conditions: HPT, Hypercholesterolaemia, Kidney disease, Malabsorption, Cholestasis.

Rectal bleeding when taking.

Question 6

What are the common s/e of Orlistat? (5)

Answer 6

GI including leadkage, flatulence, diarrhoea, urgency, fatty oil stools ( less evident if eating low fat diet)

Question 7

What counselling is given to patients taking Orlistat? (3)

Answer 7

Take multivitamins at bed time as ADEK are fat soluble vitamins.
Barrier method if on contraception and persistent diarrhoea.
Not a quick fit counselled on diet and exercise. Weight loss targets: 0.5-1kg/week.