Commony Rx Drugs - Apixaban

Question 1

What are the indications of Apixaban? (3)

Answer 1

VTE Prevention in adult px who have undergone elective hip/knee replacement surgery.

Stroke/Systemic embolism prevention in adults with non-valvular AF (NVAF) with 1 or more risk factors e.g. prior stroke/TIA, are >- 75 yrs, HPT, Diabetes, Symptomatic HF (NYHA Class >= II).

DVT + PE prevention/Tx

Question 2

What is Apixaban? (1)

Answer 2

DOAC

Question 3

When would you consider reducing the dose of Apixaban? (1)

Answer 3

Stroke/Systemic embolism in AF:
- reduce dose used in px with at least 2 of the characteristics:
- 80yrs and over
- 60kg or less
- Serum creatinine 133mcmol/L or over.

Question 4

What do you need to use to measure renal impairment? (1)

Answer 4

Creatinine clearance

Question 5

What monitoring is considered for Apixaban? (5)

Answer 5

Signs of bleeding, compliance, age, weight + renal function.