Commonly Rx Drugs - Domperidone Flashcards
1
Q
Explain the role of Domperidone. (1)
A
CINV
2
Q
What is the main difference between Domperidone and Metoclopramide? (1)
A
Doesn’t cause central effects e.g. sedation and dystonic reactions as it doesn’t readily cross BBB.
3
Q
What are the risks associated with using Domperidone as tx? (3)
A
High risk of serious ventricular arrhythmias or sudden cardiac death.
- Higher risk in px >= 60 yrs.
- Px receiving daily oral doses of > 30mg.
4
Q
Which px should not take Domperidone? (1)
A
Concomitant medication known to cause QT prolongation e.g. Ketoconazole, Erythromycin.
