Commony Rx Drugs - Citalopram

Question 1

Whar is Citalopram? (1)

Answer 1

Selective serotonin reuptake inhibitor (SSRI)

Question 2

Give e.g. SSRI. (5)

Answer 2

Escitalopram
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline

Question 3

Explain the main difference between taking SSRI + TCA. (2)

Answer 3

Less sedating and have fewer antimuscarinics and CV effects than TCAs.

Question 4

What is a common s/e of Citalopram? ()

Answer 4

GI

Question 5

Explain the general relationship between Citalopram/Escitalopram and QT intervals. (4)

Answer 5

Both can cause QT interval prolongation and not used in those with:
- Congenital long QT syndrome
- Known pre-existing QT interval prolongation
- Combination with other drug that prolong QT interval.

ECG considered with px with cardiac disease and electrolyte disturbances are to be corrected prior to tx.

Question 6

What are the dosing regimens for Citalopram? (1)

Answer 6

40mg (adults)
20mg (px > 65 yrs)
20mg (Hepatic impairment)