Commony Rx Drugs - Amlodipine

Question 1

What is Amlodipine? (1)

Answer 1

Dihydropyridine CCB relaxes smooth muscle and dilates coronary/peripheral arteries.

Question 2

What is the licensed use for Amlodipine? (1)

Answer 2

Hypertension
Angina Prophylaxis

Question 3

What is the main interaction with Amlodipine? (1)

Answer 3

Grapefruit juice increases plasma conc of Felodipine, Isradipine, Lacidipine, Lercanidipine, Nicardipine, Nifedepine , Nimodipine, Nisoldipine, Verapamil.

Question 4

What is the common s/e of Amlodipine? (1)

Answer 4

Ankle swelling (Amlodipine 10mg)

Question 5

Give e.g. of dihyropyridine CCB. (6)

Answer 5

Amlodipine
Felodipine
Isradipine
Lercanidipine
Nicardipine
Nifedipine

Question 6

What condition would you avoid giving verapamil + Diltiazem on tx? (1)

Answer 6

HF as it can further depress cardiac function.

Question 7

What other drug class should verapamil and Diltiazem not be given as a tx together? (1)

Answer 7

BB