Commony Rx Drugs - NSAIDs

Question 1

What general Rx points for NSAIDs? (3)

Answer 1

Consider individual risk factors, hx of CV/GI illness prior to Rx NSAIDs.

Naproxen (1000mg daily or less) and low dose Ibuprofen (1200mg daily or less) = favourable thrombotic CV safety profiles.

The lowest effective dose is used for shortest duration necessary to control symptoms.

Person’s need for symptomatic relief and response to tx should be re-evaluated periodically.

Question 2

What is the general relationship between NSAIDs and renal function? (1)

Answer 2

NSAIDs can precipitate renal failure and people at risk of renal impairment or retail failure (particularly older people) should avoid NSAIDs if possible.

Question 3

What does MHRA advise regarding the use of NSAIDs in renal disease? (1)

Answer 3

Consider other concomitant disease states, conditions or medicines that may precipitate reduced renal function when Rx NSAIDs.

Question 4

What type of combination therapy can increase the risk of AKI? (1)

Answer 4

ACEi + ARB + Diuretics