Commony Rx Drugs - Aripiprazole

Question 1

What is Aripiprazole? (1)

Answer 1

Antipsychotic

Question 2

What are the s/e of Aripiprazole? (4)

Answer 2

Neuroleptic Malignant Syndrome (NMS)
Elderly px with dementia-related psychosis (Cerebrovascular ADR, X for dementia-related psychosis)
Hyperglycaemia/Diabetes
Weight gain

Question 3

When would you consider reducing the dose of Aripiprazole? (1)

Answer 3

When used in adjunct to potent CYP3A4/CYP2D6i

reduce dose to 1/4 of normal dose?

Question 4

What are the drug interactions with Aripiprazole? (3)

Answer 4

Potent CYP3A4i or CYP2D6i.
CYP3A4 inducers

Question 5

What are the monitoring requirements of Aripiprazole? (2)

Answer 5

Blood concentration when signs of toxicity or given with medications that can increase its plasma levels.

Question 6

What special warning label of Aripiprazole is present? (1)

Answer 6

Check that the correct preparation is used:
- Acute (solution for injection containing aripiprazole 7.5mgml) NOT be confused with:
- Depot prep (Aripiprazole 400mg vial with solvent). Used in community/clinics for maintenance tx.