Commonly Rx Drugs - Quinine Sulphate

Question 1

What is the indication of Quinine Sulphate?

Answer 1

Leg cramps

Question 2

What are the s/s of Quinine Sulphate? (8)

Answer 2

Tinnitus
Impaired Hearing
Headache
Nausea
Disturbed Vision
Confusion
Flushing
Abdominal Pain

Stopped if occurred

Question 3

What is a rare s/e of Quinine Sulphate? (1)

Answer 3

Thrombocytopenia - hypersensitivity reactions.

Question 4

What action is done if thrombocytopenia is evident when taking Quinine Sulphate? (1)

Answer 4

Stop tx and consult a physician if signs thrombocytopenia occur e.g. unexplained petechiae, bruising/bleeding.

Question 5

What are the common drug interactions of Quinine Sulphate? (2)

Answer 5

Digoxin + Warfarin:
- Toxicity overdose = death or permanent visual loss.

Question 6

What should be done prior to continuous tx of Quinine Sulphate? (2)

Answer 6

4 week trial, stopped if there’s no benefit.
If tx continues, benefits are assessed every 3 months.

Question 7

What should patients be advised regarding the use of Quinine Sulphate? (2)

Answer 7

Warned not to exceed recommended dose.
Serious s/e = irreversible blindness and death.

Question 8

Who should not be Rx Quinine Sulphate? (1)

Answer 8

Previously experienced ADR to quinine including found in drinks.