4 - Obs - Infections in Pregnancy - Infections Flashcards
CMV - ?% maternal infection rate. 40% ?? rate
- maternal diagnosis from ? and ? avidity
- fetal diagnosis from ? at 20+ weeks
- 10% of affected fetuses ? affected
- ? common
- no ?, screening or ?
- 10% ? at birth
- develop severe ? sequelae eg hearing, ? and ? impairment or will ?
- most are not seriously affected
- what is offered?
1 vertical trans IgM + IgG amniocentesis severely deafness trt, vaccine aSx neuro mental, visual die TOP
Rubella -
most women are ?, so it is ?
? percent of fetuses affected if weeks - ? offered
- screening IDs those in need of ? immunization
-early preg infection freq causes ? fetal abnoms incl ?, ? disease, eye problems and ? retardation
immune rare high 16 TOP postnatal multiple deafness cardiac mental
Toxoplasmosis - ? percentage of fetuses ? affected.
- Screening not ? in UK
- Maternal Dx from ?
- fetal from ? at 20+ weeks
- proven infection trtd with ?
- fetal toxo trt with ? therapy
- earlier = more ? eg mental retardation, ?, ? and visual impairment
- may do what??
low permanently routine IgM amnio spiramycin combo severe convulsions spasticity TOP
Syphilis - rare
- screening ? because trt prevents ? syphilis
- active disease in preg -> ?, severe ? disease or ?
- trt with prompt ?
routine congenital miscarriage congenital stillbirth prompt benzylpenicillin
Herpes simplex virus - common
- ? infection rare but ?
- ? risk of neonatal ? if primary infection within ? weeks of delivery (therefore a ?? is indicated)
- drug of choice? given to who?
- it is not ?
- diagnosis is usually clear ?
- mgmt: refer to ???, risk v low if ? infection present
neonatal serious high herpes 6 C/s aciclovir - to neonate and mother (in late preg) teratogenic clinically GUM recurrent
GBS - high maternal ? rate - major cause of ? neonatal illness.
Trt with ? penicillin of ?-? groups +/- positive ? trimester screen greatly ? neonatal infection
- how is vert trans prevented?
-trt is RFs for ?? or if ? found incidentally (no screening in UK)
carrier intrapartum high-risk 3rd reduces IV penicillin vert trans GBS
GAS - common cause of ??, occasionally causes ..
1 - severe illness in ? with ?
2 - ? sepsis
-most common bacterium ass w ? death - ? is leading cause
-infected fetus often ? in utero and ? ensues
-trt - ? and supportive therapy
sore throat preg with chorioamnionitis puerperal maternal sepsis dies labour ABx
Herpes zoster - many are ?
- severe ? illness in ?
- infection weeks occasionally teratogenic
- infection just before ? can cause severe ? infection - so ? given to ?
immune maternal preg 20 delivery neonatal IgC neonate
Hep B - carriage common in ?-? women. High ? rate,
- high ? disease rate and ? in neonate
- universal ? ID’s neonates in need of ?
- neonatal ? reduces risk of infection by >90%
high-risk transmission chronic mortality screening immunoglobulin immunization
Chlamydia - ?% in pregnancy -neonatal ? and ? labour -ABx may prevent ?? so screening probably worthwhile -trt with ? or ?
5% conjunctivitis preterm preterm labour azithro/erythromycin
BV - common
- ass with ? ?
- ? and ? if previous preterm labour
- late ? also increased
- trt = oral ?
preterm labour
screening and trt
miscarriage
clindamycin
Parvovirus - fetus develops ? and subsequent ?
-if IgM ?, surveillance for ? with middle ? artery ? and ultrasound. ? ? transfusion if anaemia ?
anaemia hydrops \+ve anaemia cerebral doppler in utero severe
