2 - Derm - Skin + Systemic disease - Major mechanisms

Question 1

what are the 2 major mechs?

Answer 1

skin and internal organs targeted by the same disease process

The internal disease may cause a skin manifestation by an often unclear mechanisma

Question 2

Targeted by same disease process.. 4 diseases/types of diseases

Answer 2

gout
vasculitis
connective issue disease
hyperlipidaemia

Question 3

what can lead to coeliac and dermatitis hepetiformis? what happens in dermatitis hepetiformis?

Answer 3

gluten hypersensitivity

chronic recurrent pruritic rash, usually excoriated vesicles, common on extensor surfaces arms and legs

Question 4

skin manifestation of

• gout
• vasculitis

Answer 4

gout - uric acid crystals deposited in skin as well as joints - causing tophi
vasc - both skin and organ vessels affected

Question 5

skin manifestation of

• hyperlipidaemia
• what conn tissue disease can affect skin

Answer 5

• xanthomata

- SLE, systemic sclerosis, dermatomyositis

Question 6

skin manifestation of malignancy…4

Answer 6

acanthosis nigricans - abdo malignancy
dermatomyositis - multi malignancy
generalised pruritis - lymphoma
superficial thrombophlebitis - pancreatic cancer

Question 7

DM skin manifestation - 5

Answer 7

diabetic ulcers
skin infections
necrobiosis lipoidica
diabetic dermopathy
granuloma annulare

Question 8

Liver disease skin manifestations

Answer 8

jaundice
pruritis
spider naevi
palmar erythema
leukonychia