2 - Derm - Skin + Systemic disease - Drug eruptions 1

Question 1

how many inpatients affected

common culprits..7

Answer 1

10%

ABx, NSAIDs, thaizides, ACEIs, OCP, allopurinol, anticonvulsants

Question 2

Types of eruption - 4

Answer 2

toxic erythema
urticaria
fixed drug eruptions
erythema multiforme

Question 3

Toxic erythema

-how common? - similar to?

Answer 3

most common eruption

like measles - morbilliform

Question 4

Toxic erythema - features and assoc features, and when?

Answer 4

pruritic and erythematous maculopapular eruption on trunk

fever malaise, eosinophilia - often within 2 weeks of therapy

Question 5

Toxic erythema - causes

Answer 5

penicillins - amox in glandular fever (almost 100%)0
cephalosporins
anticonvulsants

Question 6

Urticaria - when? ass w? skin change?

Answer 6

rapid onset after drug
may be ass w angiooedema/anaphylaxis

wheals (transient pale papules with pink margins)

Question 7

Urticaria - causes

Answer 7

penicillins and cephalosporins (T1HS via IgE)

Morphine and codeine (mast cell activation)

Question 8

Fixed drug eruption - skin change? where and when?

Answer 8

circle oval red brown lesions , may ulcerate

in same location every time a drug is taken

Question 9

Erythema multiforme is a ..?

list in order of increased severity

Answer 9

is a spectrum of conditions

erythema multiforme
stevens johnson syndrome
toxic epidermal necrolysis