11 - Derm - Acne - Background

Question 1

most common form? a disease of what? characterised by 3 things?

Answer 1

acne vulgaris
pilosebaceous glands
comedones, papules, pustules

Question 2

effects % between 12-24? more common in who? more persistent in who?

Answer 2

85%
male
women - 10% may persist to 40’s

Question 3

4 myths of acne

Answer 3

only affects teens
caused by poor hygiene
caused by fatty foods
improved by drinking a lot of water

Question 4

pathogenesis 3 steps?

Answer 4

1 - increase in sebum excretion rate SER
2 - ductal hypercornification
3 - proprionibacterium acnes infection

Question 5

1 - increased SER - due to? results in?

Answer 5

increased circulating androgens or increased sensitivity to androgens
results in seborrhea (greasy skin)

Question 6

2 - ductal hypercornification 4 steps

Answer 6

hyperkeratosis and abnormal desquamation of follicle
?free fatty acid levels in sebum association?
leads to obstruction of follicle and retention of sebum
results in comedone formation

Question 7

3 - proprionibacterium acnes infection - 3 steps

Answer 7

• normally a commensal bacteria of skin
• thrives in obstructed follicle
• releases inflammatory mediators
• inflam - lead to follicular rupture and spread to surrounding dermis