10 - Derm - Fungal infections - Antifungals Flashcards

1
Q

3 types of fungal infections

A

superificial - hair nails etc
subcut - dermis, subcut tissue
deep - direct/haematogenous spread

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2
Q

3 types of antifungal meds

A

azoles
allylamines
griseofulvin

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3
Q

2 examples of azoles

1 example of allylamines

A

miconazole
ketoconazole

terbinafine

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4
Q

azoles - metabolism? therefore…

A

met by CP450 - increased effects of ciclosporin, phenytoin

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5
Q

what is special about ketoconazole

A

risk of hepatitis, reduced androgen synthesis

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6
Q

allylamines - what is rare? route?

A

PO and top

adverse effects rare

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7
Q

griseofulvin - adverse effects? interacts with?

A

headaches, nausea, photosensitive rash

interacts with phenobarbitoin

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