10 - Derm - Fungal infections - Antifungals Flashcards
1
Q
3 types of fungal infections
A
superificial - hair nails etc
subcut - dermis, subcut tissue
deep - direct/haematogenous spread
2
Q
3 types of antifungal meds
A
azoles
allylamines
griseofulvin
3
Q
2 examples of azoles
1 example of allylamines
A
miconazole
ketoconazole
terbinafine
4
Q
azoles - metabolism? therefore…
A
met by CP450 - increased effects of ciclosporin, phenytoin
5
Q
what is special about ketoconazole
A
risk of hepatitis, reduced androgen synthesis
6
Q
allylamines - what is rare? route?
A
PO and top
adverse effects rare
7
Q
griseofulvin - adverse effects? interacts with?
A
headaches, nausea, photosensitive rash
interacts with phenobarbitoin