VIRAL HEPATITIS Flashcards
HEPATITIS VIRIDAE
Viral Hepatitis – _____ of the ________
Infection
liver hepatocytes
____ known types of Hepatitis Virus
_____ RNA Viruses (________________ )
_____ DNA Viruses (________________ )
6
5; HAV, HCV, HDV, HEV, & HGV
1; HBV
HEPATITIS VIRIDAE
HAV & HEV are transmitted via __________ route
All others are transmitted via ___________
fecal-oral
blood to blood contact
HEPATITIS VIRIDAE
_______________ are transmitted via fecal-oral route
All others are transmitted via blood to blood contact
HAV & HEV
HEPATITIS VIRIDAE
It could be a sudden illness with a ___________ course followed by __________ (_____ viral hepatitis)
It could have a prolonged course of _______ or __________ ( _______ viral hepatitis)
mild to severe
complete resolution; acute
active disease or silent asymptomatic infection; chronic
HEPATITIS A VIRUS
Naked or Enveloped
__________ capsid
_____ stranded RNA
Family – ______viridae
Naked
icosahedral
+ss
Picorna
HEPATITIS A VIRUS
A stands for _____ (_____)
______ cases reported each year
Anal
Anus
25,000
HEPATITIS A VIRUS
(Young or Old?) (children or adults?) are mostly frequently affected
_________ tests can help establish diagnosis
Young children; Serologic
HEPATITIS A VIRUS
HAV capsid is antigenic
Antibodies produced last few years & is protective
A new vaccine is available
T/F
T
F
T
HAV capsid is antigenic
Antibodies produced last indefinitely & is protective
A new vaccine is available
HEPATITIS B VIRUS
The intact virus called “____________ ”
Naked or Enveloped?
________ capsid studded with _______
Dane particle
Enveloped
Icosahedral
protein spikes
HEPATITIS B VIRUS
_______ stranded (DNA or RNA?) core with associated ————- enzyme
Belongs to the _______________ family
Double
DNA
DNA polymerase
Hepadnavirus
HEPATITIS B VIRUS
Many antigenic sites:
– Hepatitis B _____ antigen (_____)
– Hepatitis B ______ antigen (_____)
– Hepatitis B ___ antigen (______)
surface; HBsAg
core; HBcAg
E; HBeAg
HEPATITIS B VIRUS
Virus present in human _____
HBV is (a bit or very?) contagious
Causes ______________ hepatitis
fluid
Very
both acute & chronic
HEPATITIS B VIRUS
Serologic tests also important in diagnosis
–__________________ – New infection
–____________ – old infection
–_______ – High Infectivity
–__________ – Low Infectivity
IgM anti-HBcAg
IgG anti-HBcAg
HBeAg
Anti-HBeAg
HEPATITIS B VIRUS
Serologic tests also important in diagnosis
– IgM anti-HBcAg –_____ infection
– IgG anti-HBcAg –_______ infection
– HBeAg – _____ Infectivity
– Anti-HBeAg –____ Infectivity
New
old
High
Low
HEPATITIS C VIRUS
Naked or Enveloped ?
_________ RNA virus
Causes ________________ hepatitis
Enveloped
icosahedral
both acute and chronic
HEPATITIS C VIRUS
Most implicated in the development of ________ and _________
Anti-HCV antibodies develops ________ after exposure
carcinoma and liver cirrhosis
months
HEPATITIS C VIRUS
Blood donors are also screened for HCV
Diagnosis same as HBV
T/F
T
T
HEPATITIS C VIRUS
There is vaccine against HCV
T/F
F
No vaccine against HCV
HEPATITIS C VIRUS
High rate of treatment failure
T/F
T
HEPATITIS C VIRUS
Treatment with ______agent (_____)
Antiviral
Ribavirin
HEPATITIS C VIRUS
Belongs to the ————- family
Flavivirus
HEPATITIS DELTA VIRUS (HDV)
(DNA or RNA?)!virus, with _____ nucleocapsid Transmitted as HBV & HCV
Can only replicate ____________
RNA
helical
with the help of HBV
HEPATITIS DELTA VIRUS (HDV)
______ + HDV= Big Bad Dude
Belongs to the ________ family
HBV; Deltavirus
HEPATITIS DELTA VIRUS (HDV)
Infection occurs in 2 ways;
a)__________ of _____________
b) HDV infects ________________
co-infection; HBV & HDV transmitted together
a person with chronic HBV infection
HEPATITIS DELTA VIRUS (HDV)
Serological tests is useful
T/F
F
Serological tests not useful as antibodies last for a while
HEPATITIS DELTA VIRUS (HDV)
No treatment available for infection
T/F
T
HEPATITIS DELTA VIRUS (HDV)
____________ is currently the only way to protect against HDV
Control of HBV infection
HEPATITIS E VIRUS (HEV)
Referred to as ______ hepatitis, as it ________________
Transmitted by ________
E stands for ———-
non-A
shares similarities with HAV
fecal-oral route
Enteric
HEPATITIS E VIRUS (HEV)
Endemic to Asia, India, Africa and Central America
Belongs to the _______ family
Calicivirus
HEPATITIS G VIRUS (HGV)
(DNA or RNA?) virus
Belongs to the _______ family
Transmitted by _________
RNA
Flavivirus
blood and blood products
Hepatitis ____ virus has not conclusively shown to cause serious liver disease
G
