Bacteria skin infections Flashcards

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1
Q

Functions of the skin

Prevents excessive ______
Important to _____ regulation
Involved in _____ phenomena
Barrier against __________

A

water loss

temperature

sensory

microbial invaders

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2
Q

Wounds allow microbes to infect deeper tissues

T/F

A

T

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3
Q

The skin has normal flora just like any other part of the body

T/F

A

T

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4
Q

The skin’s flora is composed of _______,________, and ________ bacteria etc

A

aerobic cocci, aerobic and anaerobic coryneform

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5
Q

Major function of skin flora is to ___________ by Providing __________ for pathogenic microorganism

By hydrolizing ______ of _____ to produce _________ which are toxic to many bacteria

A

prevent skin infections

ecological competition

lipids of sebum

free fatty acids

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6
Q

Microbiota

____tolerant
Dense populations in skin _____
Total numbers determined by ________ and _________
May be opportunistic pathogens

A

Halo

folds

location and moisture content

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7
Q

The ecology of particular areas of the skin is determined by the availability of moisture, presence of sebaceous lipids, and gaseous environment

T/F

A

T

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8
Q

Skin

The process of infection involves the interaction between two organisms-the host and the invader

The clinical changes depends on the organisms, its virulence, and patient’s immunity

T/F

A

T

T

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9
Q

INTRODUCTION

(Acute or Chronic?) bacteria infections generally produce some or all of the classical features of acute inflammation

These cardinal signs includes;
________,_________,__________,_________

A

Acute

erythema(redness), swelling/oedema, heat/warmth, pain/discomfort

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10
Q

Most skin flora categorized in three groups:

————
__________
___________

A

Diphtheroids
Staphylococci
Yeasts

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11
Q

Most skin flora categorized in three groups:

Diphtheroids (_________ and ________)
Staphylococci (Staphylococcus _____)
Yeasts (______ and _______)

A

Corynebacterium and Propionibacterium

epidermidis

Candida and Malassezia

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12
Q

Bacteria skin infections are very (common or rare?)

A

Common

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13
Q

____,__________, and ________ are the most common bacteria skin infections
Carbuncles,

A

Cellulitis, impetigo and folliculitis

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14
Q

Impetigo: infection of _______Layer of epidermis

Ecthyma: infection of ____________ Of epidermis

Erysipelas: infection of _________

A

sub corneal

full thickness

upper half dermis

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15
Q

Cellulitis : infection of the ________

Necrotizing factors: infection of ______ and ______

A

lower half of dermis

subcutaneous fat and deep fascia

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16
Q

FOLLICULITIS

Introduction- folliculitis is infection of the ________.

Classification is by the _______of the hair
follicles which could be ______ or ______ folliculitis.

A

hair follicles

depth of involvement

superficial or deep

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17
Q

FOLLICULITIS

Hair follicle can become inflamed by ______ injury, _______ or infection that leads to folliculitis.

A

physical; chemical irritation

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18
Q

A furuncle develops when the ________ and ____________ are involved.

A

entire follicle

surrounding tissues

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19
Q

Folliculitis: Causative Agent
Most commonly caused by ______
_____ tolerant
Tolerant of _______

A

Staphylococcus

Salt

desiccation

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20
Q

Signs and symptoms of folliculitis

Infection of the hair follicle often called a _________

Called a _____ when it occurs at the eyelid base

Spread of the infection can produce _________ or ________

A

pimple

sty

furuncles or carbuncles

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21
Q

Epidemiology and pathogenesis Of skin infections

The most common form is ______________

It could be multiple or single lesion and can appear on any ———————including head, neck, trunk,buttocks and extremities

A

superficial folliculitis

skin bearing hair

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22
Q

Epidemiology and pathogenesis Of skin infections

commensal organisms like ____ can be seen in immunocompromised.

Occasionally, gram negative folliculitis can be seen in ________ patients treated with (short or long?) courses of antibiotics.

A

yeast

acne vulgaris

Long

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23
Q

Epidemiology and Pathogenesis Of skin infections

The use of hot tubs and whirl pools has been classically associated with __________.

Patients with _________ are at increased risk because of higher rate of colonization with S. aureus.

______,________, or _________hair, use of topical _______, hot and humid weather, and diabetes mellitus are all predisposing factors
.

A

Pseudomonas folliculitis

atopic dermatitis

Shaving, plucking or waxing

corticosteroids

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24
Q

Clinical features of bacterial skin infections

A (shallow or deep?? folliculitis appears as (small or large?) , tender, erythematous _____, often with a _______.

The lesions may be ________ and slighly tender. The lesions are ______ and may scar.

A

Deep ; large

papules; central pustule.

pruritic; painful

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25
Q

Diagnosis and Differential diagnosis

The diagnosis of bacterial folliculitis is usually based on ______

Gram stain and bacterial cultures can help to identify the causative organisms, especially in recurrent or treatment-resistant cases.
The differential diagnosis includes other forms of folliculitis as well as ___________,__________,____________ and _________

A

clinical inspection.

acne vulgaris, rosacea, ,pseudofolliculitis barbae , and keratosis pilaris

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26
Q

TREATMENT of skin infections

antibacterial washes that contain _______ or _______

Antibacterial ointments (_______ or __________ 2%)

A

chlorhexidine or triclosan.

bacitracin or mupirocin

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27
Q

Treatment of skin infections

appropriate oral b-lactamase inhibitor antibiotics, _______ and ________ (e.g clindamycin), _______ can be used for serious cases.

A

macrolides and lincosamides

flouroquinolones

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28
Q

PSEUDOMONAL FOLLICULITIS

Pseudomonal folliculitis is associated with the use of _________,_______ and, rarely, ____________.

A

whirlpools, hot tubs

swimming pools

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29
Q

PSEUDOMONAL FOLLICULITIS

P.________ gains entry via ________ or _____ in the skin.

The lesions arise _____ after exposure and resolve in ________

A

aeruginosa

hair follicles; breaks

8–48 hours

7–14 days.

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30
Q

Clinical features of Pseudomonal folliculitis

Associated symptoms do not imply __________ of P. aeruginosa

These symptoms includes ; __________,_______,_________

A

systemic spread

painful eyes, malaise, fever

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31
Q

Diagnosis of Pseudomonal folliculitis

The diagnosis can be confirmed by isolation of P. aeruginosa, especially serotype ______, from lesions.

The differential diagnosis includes _____________ folliculitis, insect bites, ________,___________, ________ folliculitis, miliaria and acne vulgaris.

A

O-11

S. aureus

papular urticaria, Majocchi’s granuloma

eosinophilic

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32
Q

TREATMENT
Treatment is generally not indicated in immunocompetent hosts as it is usually a self-limited process.
Lesions usually resolves spontaneously within seven to ten days
In the case of widespread eruptions, recurrences, immunosuppression or associated systemic symptoms, an oral fluoroquinolone and topical gentamicin can be used.

A
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33
Q

TREATMENT
Treatment is generally not indicated in immunocompetent hosts as it is usually a self-limited process.
Lesions usually resolves spontaneously within seven to ten days
In the case of widespread eruptions, recurrences, immunosuppression or associated systemic symptoms, an oral fluoroquinolone and topical gentamicin can be used.

A
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34
Q

PREVENTION of Pseudomonal folliculitis

Personal hygiene and maintenance of _____ and _______
Hand hygiene
Avoid sharing of _______

A

pools and tubs

towels

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35
Q

Furuncles and Carbuncles

A furuncle is a ______,_________ , firm or fluctuant mass of _______ ———- material arising from the _________.

It is commonly known as ______ or ________

A

tender, erythematous

walled-off ; purulent

hair follicles

boil or abscess.

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36
Q

Furuncles and Carbuncles

Carbuncles are an aggregate of ____________________ that form (broad or narrow?) (flat or swollen?) , erythematous, (shallow or deep?) and (painful or painless?) masses that usually open and drain through ________.

A

infected hair follicles

Broad; swollen; deep; painful

multiple tracts

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37
Q

Furuncles
extended ______,_______, _______ and tenderness

Carbuncles
Numerous sites of _________, Usually in areas of ________ skin

A

redness, pus, swelling

draining pus; thicker

38
Q

EPIDEMIOLOGY AND PATHOGENESIS

Furuncles tend to occur in _______ and __________

________ is the most common causative organism, though recurrent furuncles in the _________ region can be secondary to (aerobic or anaerobic?) bacteria.

A

adolescents and young adults.

S. aureus ; anogenital region

anaerobic

39
Q

Five percent of cutaneous abscesses are ______, caused by a _________ reaction (e.g. _______________)

A

sterile

foreign body

ruptured cyst

40
Q

Furuncles

Predisposing factors include (acute or chronic?) _______ carriage,

Diabetes mellitus, obesity, poor hygiene,
Immunodeficiency states, such as in chronic granulomatous disease and ____ syndrome.

A

Chronic

S. aureus

Job

41
Q

Furuncles

The most common locations are the ___,______,______ ,______,_______ and perineum. Sites prone to ______ or _____ , such as the area ______, are distinctly susceptible.

A

face, neck, axillae, buttocks, thighs

friction or minor trauma

under a belt

42
Q

Furuncles usually begin as a _____,_____, red nodule that ______ and becomes ______ and _________; _______ results in decreased pain.

A

hard, tender

enlarges

painful and fluctuant

rupture

43
Q

Furuncles

Epidemiology: endogenous
Two species commonly found on the skin
– ________ ————
– _______ ————

Transmitted through _________ or _______

A

Staphylococcus epidermidis
Staphylococcus aureus

direct or indirect contact

44
Q

Treatment of furuncles

________ (semi-synthetic penicillin)
______ or _______ used to treat resistant strains
May require —————-

– Prevention of furuncles
Hand _______
Proper ——————- and surgical openings, aseptic use of catheters or indwelling needles, and appropriate use of antiseptics

A

Dicloxacillin

Vancomycin or Bactrim

surgical draining

antisepsis; cleansing of wounds

45
Q

Scalded Skin Syndrome

__________ scalded skin syndrome (SSSS)
Bacterial agent is __________

——— mediated disease

A

Staphylococcal

Staphylococcus aureus

Toxin

46
Q

Signs & Symptoms of SSSS
•Skin appears ———- (______)
–Other symptoms include malaise, irritability, fever; nose, mouth and genitalia may be _______

A

burned; scalded

painful

47
Q

SSSS

__________ toxin released at infection site
causes ——- in epidermis
– (Inner or Outer?) layer of skin is lost

-Causes ____ loss and increase susceptibility to __________

A

Exfolative

split

Outer

body fluid; secondary infection

48
Q

Epidemiology of SSSS

–___% of S. aureus strains produce _______

– Disease can appear at any age group
•Most frequently seen in ______,_______ and immunocompromised
– Transmission is generally _________

A

5; exfoliatins

infants, the elderly

person-to-person

49
Q

Impetigo (________)

Characterized by ____ production

A

Pyoderma

pus

50
Q

Impetigo

Causative agents:
– _________ ______
– 80% cases caused by ________
– Others caused by _______ _______

A

Pyodermic cocci

S. aureus

Streptococcus pyogenes

51
Q

Impetigo

– Others caused by Streptococcus pyogenes
Group ___ Streptococcus
– Gram- ______ coccus, arranged in _____, __ -hemolytic

A

A; positive

chains; β

52
Q

Signs & Symptoms of impetigo

•(Superficial or deep?) skin infection
•Blisters just below ________ layer
•Blisters replaced by _________
•There is little ______ or _____
•Lymph nodes enlarge near area
•May result in _______

A

Superficial ; outer skin layer

weepy yellow crust

fever or pain

erysipelas

53
Q

Epidemiology of impetigo
– most prevalent among (children or adult?)
Most affected are ______ years of age
– Disease primarily spread from __________
Also spread by ————-

A

Children

two to six

person-to-person

insects and fomites

54
Q

Prevention and treatment of impetigo

– Prevention is directed at ________ and ________ of individuals with impetigo
– ________ treatment of wounds and application of ________ can lessen chance of infection
– Active cases are treated with ________, ________ or ________

A

cleanliness and avoidance

Prompt ;antiseptics

penicillin, erythromycin or vancomycin

55
Q

Acne

_______-associated lesion

Causative agent
Most serious cases caused by __________ ————

– Epidemiology: ____genous

A

Follicle

Propionibacterium acnes

endogenous

56
Q

Acne

Propionibacterium acnes

Gram- _______,

______-shaped ______

feed on ______ and ______ in ______ pores & ______

A

positive; rod

diphtheroids

sebum ; keratin

plugged ; follicles

57
Q

Prevention of Acnes
remove ______ as often as possible

A

oils

58
Q

Treatment of impetigo

•prophylactic _________
•_________ or _________ acid
•New treatment uses _________ ________
•_________ in severe cases

A

tetracycline

Benzoly peroxide ; salicylic acid

blue light radiation

Accutane

59
Q

ERYSIPELAS
Erysipelas is primarily an infection of the _______ with significant _______ involvement.

It has a distinctive clinical presentation and is most often caused by ________ _______ (group ___ streptococci).

A

dermis , lymphatic involvement.

Str. pyogenes (group A streptococci).

60
Q

Pathogenesis and Epidemiology of Erysipelas

Erysipelas is a disease of the very ________ , the ________, the ________,
and those with ________ or _______ ——- ulcers.

A

young, the aged, the debilitated,
and those with lymphedema or chronic cutaneous ulcers.

61
Q

Pathogenesis and Epidemiology of Erysipelas

(Women or Men?) outnumber (women or men?) , except for very (young or old?) patients, where (boys or girls?) are more commonly affected.

There is ____eased frequency during the warmer/hot months and most cases are isolated.

A

Women

Men; young

Boys

incr

62
Q

Most cases of erysipelas are caused by infection with group ____ streptococci and less often by group _____________

S. aureus, Pneumococcus species, Klebsiella pneumoniae, Yersinia enterocolitica, and Haemophilus influenzae type b have been known to cause an erysipelas-like infection

A

A

G, B, C or D.

63
Q

Clinical Features of erysipelas

The classic lesion of erysipelas, with its well-defined margins, involves the _________ .

Nowadays, however, the _________ is the most common location.

After an incubation period of _________, there is an abrupt onset of fever, chills, malaise and nausea.

A few hours to a day later, a (small or large?) plaque of _________ develops that progressively spreads

A

face ; lower extremity

2 to 5 days

a small plaque of erythema

64
Q

Clinical Features of erysipelas

The area is clearly demarcated from uninvolved tissue, hot, tense and indurated with _____________.

The affected area is painful to ________ and maybe ________ to touch

. Regional ________ is normally present.

________, ________, ________ and small areas of ________ may also form.

A

non-pitting edema.

palpation ; warm

lymphadenopathy
.
Pustules, vesicles, bullae and small areas of hemorrhagic necrosis .

65
Q

Complications of erysipelas are (common or rare?) and usually occur in patients with ____________.

When the infection resolves, _______ and postinflammatory _______ changes may occur.

A

rare ; underlying disease.

desquamation

pigmentary

66
Q

Diagnosis and Differential diagnosis of erysipelas

Diagnosis is based primarily on ________

Routine laboratory evaluation will show an elevated _________with a (left or right?) shift.

Blood cultures are positive in only about __% of cases.

_____ from local ports of entry, pustules or bullae, the _____, and the _____ are helpful.

A

clinical findings.; leukocyte count

Left ; 5; Swabs

Throat, nares

67
Q

Diagnosis and Differential diagnosis of erysipelas

Culture of _______ biopsy specimens and the injection-_______ method yield poor results, especially in immunocompetent host

. Anti- _______ and ______ titers are good indicators of streptococcal infections.

Direct ________ and —————- tests can be used to detect streptococci within skin specimens.

A

skin ; re- aspiration

DNase B and ASO

immunofluorescence and latex agglutination

68
Q

Differential Diagnosis of erysipelas

________ and other soft tissue infections (e.g. ________, ________ ________) as well as inflammatory causes of ‘_______________’ (e.g. ________ syndrome, contact ________)

A

cellulitis

erysipeloid, necrotizing fasciitis.

‘pseudocellulitis’

. Sweet’s syndrome

dermatitis

69
Q

Treatment of erysipelas

A 10–14-day course of _______ is the treatment of choice for erysipelas caused by _______.

Although macrolides such as _______ may be used in _______ patients, there has been an increase in ________ among certain strains of Str. pyogenes.

Hospital admission and intravenous or intramuscular antibiotics should be reserved for _______ and ________ patients.

A

penicillin ; streptococci.

erythromycin ; penicillin-allergic

macrolide resistance

children and debilitated patients.

70
Q

cellulitis

Cellulitis is an infection of the (superficial or deep?) dermis and ______ caused most commonly by _______ and ______

A

Deep dermis

subcutaneous tissue

Str. pyogenes and S. aureus

71
Q

Epidemiology and Pathogenesis
Cellulitis in immunocompetent adults is most often caused by ________ or ________.

The majority of cellulitis in childhood is caused by ________, and less commonly by ________ .

A mixture of Gram-________ cocci and Gram-________ aerobes and anaerobes is associated with cellulitis surrounding ________ and ____________

A

Str. pyogenes or S. aureus.

S. aureus ; H. influenzae

positive ;negative

diabetic ulcers and decubitus ulcers.

72
Q

pathogenesis of cellulitis

Bacteria may gain access to the ________ via an ________ or a ________ route.

Usually, in immunocompetent patients, a _____________________ is responsible

A

dermis ; external ; hematogenous

a break in the skin barrier

73
Q

Cellulitis

In immunocompromised patients, a __________ route is most common.

Recurrent bouts of cellulitis may be caused by damage to the __________ system (e.g. previous __________________, __________ harvest or prior episode of _______________)

A

blood borne route

lymphatic system

lymph node dissection

saphenous vein harvest

of acute cellulitis

74
Q

Lymphedema, alcoholism, diabetes mellitus, intravenous drug abuse, and peripheral vascular disease all predispose to cellulitis.

T/F

A

T

75
Q

Clinical features of cellulitis

Cellulitis is often preceded by systemic symptoms, such as fever, chills and malaise.

rubor (erythema), calor (warmth), dolor (pain), and tumor (swelling).

The lesion usually has (ill or well?)-defined, (palpable or non-palpable?) borders.

In severe infections, vesicles, bullae, pustules or necrotic tissue may be present.

A

Ill

Non-palpable

76
Q

Clinical features of cellulitis

Ascending ______ and ________ lymph node involvement may occur.

Children usually have cellulitis of the _______ and ______ region, whereas in adults the _________ are most often affected

A

lymphangitis

regional

head and neck

extremities

77
Q

Clinical features of cellulitis

In intravenous drug abusers, the ___________ are often involved.

Complications are (common or rare?) , but include ___________ (if caused by a ___________ strain of streptococci), ___________ and ___________ bacterial ___________.

Damage to ___________ can lead to recurrent cellulitis.

A

upper extremities ; rare

acute glomerulonephritis ; nephritogenic

lymphadenitis ; bacterial endocarditis.

lymphatic vessels

78
Q

Diagnosis and differential
diagnosis of cellulitis

The diagnosis of cellulitis is usually ________ . The leukocyte count is usually ________ or ________

Blood cultures are almost always ________ in immunocompetent hosts.

An important exception is ________ cellulitis, where there is usually ________ leukocyte count with a (left or right ?) shift and ________ blood cultures.

In children and immunocompromised patients, atypical organisms are more common, and ________ and ________ may be appropriate

A

clinical ; normal

only slightly elevated ; negative

H. influenzae ; an increased

left ; positive

needle aspiration and skin biopsy

79
Q

differential diagnosis of cellulitis

The differential diagnosis of lower extremity cellulitis includes _________________ and other inflammatory diseases, such as _________________, _________________, and _________________ (especially _________________).

A

deep vein thrombosis

stasis dermatitis

superficial thrombophlebitis

panniculitis

lipodermatosclerosis

80
Q

Treatment of cellulitis

In most cases of cellulitis, treatment should be targeted against
_________ and _________.

Mild cases require a ___- day course of an _________ that has good Gram- _________ coverage.

Hospitalization and parenteral antibiotics should be reserved for patients who are seriously ill and those who have _________ cellulitis.

A

Str. pyogenes and S. aureus

10- ; oral antibiotic

Gram- positive

facial cellulitis.

81
Q

Treatment of cellulitis

_________ or _______ ulcers complicated by cellulitis require ____________ coverage (e.g. piperacillin/tazobactam or, in penicillin-allergic patients, metronidazole plus ciprofloxacin).

A

Diabetic or decubitus ulcers

broad-spectrum coverage

82
Q

Impetigo

Impetigo is a (common or rare?) , (mildly or highly?) contagious, (superficial or deep?) skin infection that primarily affects (children or adults?).

A

common

highly

superficial

children.

83
Q

Impetigo

The condition presents in both ________ and _________ forms .

The primary pathogens in these forms of impetigo are _________ and, less commonly, _________ (_________).

A

both non-bullous and bullous forms .

Staphylococcus aureus

group A b-hemolytic Streptococcus (Streptococcus pyogenes).

84
Q

Worldwide, ________ is the most common bacterial skin infection in children.

A

impetigo

85
Q

Predisposing factors to impetigo include ______ temperature, ——- humidity, ____ hygiene, an ________ and skin ______.

A

warm

high

Poor

Atopic diathesis

trauma

86
Q

Nasal, axillary, pharyngeal and/or perineal S. aureus colonization imparts an increased risk for developing impetigo

T/F

A

T

87
Q

Pathogenesis
Non-bullous impetigo

Non-bullous impetigo (or ______ impetigo) is usually caused by ______ and, on occasion, ______.

Infection occurs at (minor or major?) sites of trauma (e.g. chickenpox, insect bite, abrasion, laceration, burn).

Trauma exposes ______ proteins which allow the bacteria to ______, ______ and establish infection

A

crusted ; S. aureus

Str. pyogenes.

minor

cutaneous

adhere, invade and establish infection

88
Q

Pathogenesis: Bullous impetigo

The etiologic agent of bullous impetigo, _________ , elaborates several exfoliative toxins and bullous impetigo is considered a (localized or generalized?) form of staphylococcal _________ syndrome .

In both diseases, _________ formation is mediated by _________ binding to the _________ protein , _________ and cleaving its extracellular domain, thus leading to _________ within the _________ _________ layer.

A

S. aureus; exfoliative toxins

localized ; scalded skin syndrome .

blister ;exfoliative toxin

desmosomal ; desmoglein 1

acantholysis ; epidermal granular layer.

89
Q

Bullous Impetigo

In contrast to non-bullous impetigo, lesions can occur on _______ .

Although the differential diagnosis for non-bullous and bullous impetigo is extensive, the history , physical examination and ———- tests can often establish the diagnosis.

A

intact skin

ancillary

90
Q

TREATMENT of impetigo

Primary treatment involves _______ care, including cleansing , removal of _______, and application of _______.

For healthy patients with a few, isolated superficial lesions and no systemic symptoms , either _______ 2% _______ or _______ cream or ointment can be prescribed.

For patients with limited disease, there is evidence that these _______ medications are at least equally (if not more) effective than _______

A

Local wound ; crusts

wet dressings.

mupirocin ; ointment

fusidic acid ; topical medications

oral antibiotics

91
Q

Majority of bacterial skin infection are caused by ______________________ species.

A

Staphylococcus and Streptococcus

92
Q

Antibiotics are used _______ with consideration for _______ pattern

Gram negative coverage is indicated in ________ under ____years and patient with _________ or immunocompromised

A

emperically

resistance

children; 3yrs

diabetes