Paramyxoviruses, Mumps Flashcards
Paramyxoviridae
_________virus
______virus
_______virus
Paramyxovirus
Pneumovirus
Morbillivirus
Paramyxoviridae
Paramyxovirus - _________ , _________
Pneumovirus - _________ virus
Morbillivirus - _________
parainfluenza, mumps
respiratory syncytial virus
measles
Rubella virus is a member of the _____viridae!!!
Toga
Structure: Paramyxoviridae
(Naked or Enveloped?) 150-300 nm
_______ , _________ symmetry
(SS or DS?) (DNA or RNA?) ,antisense monopartite
Enveloped
helical ; pleomorphic
SS ; RNA
Viral Proteins- Paramyxoviridae
They all possess
______-directed ________________
______________ - parainfluenza and measles
____________ - parainfluenza
RNA-directed RNA polymerase
Hemagglutinin
Neuraminidase
Neuraminidase & hemagglutinin activities are (same or different?) sites of the (same or different ?) protein
different
same
_______ protein causes syncytia formation
Fusion
Fusion protein causes ________ formation
syncytia
Parainfluenza Viruses
Paraflu:Clinical manifestions
mild or severe _________ of the ____________________________
particularly in (children or adults?)
infections
lower and upper respiratory tract
children
Paraflu: Classification
types ________ in humans
type ___ subtypes: ______
1,2,3,4
4
A & B
Paraflu: Epidemiology
occurs worldwide
usually endemic
primarily in _________________
reinfections is (common or rare?)
young children
Common
Paraflu: Diagnosis
clinical symptoms are (specific or nonspecific?)
_________ virus
Detect __________
Detect rise in ______________
nonspecific ; Isolate
viral antigens
specific antibodies
Vaccine for parainfluenza is called??
No vaccine is available for Parainfluenza
Mumps virus
Mumps:Clinical manifestions
(localized or systemic?) ________ infection
children & young adults
________ of ________ glands( especially the ________ gland)
systemic ; febrile
swelling ; salivary glands
Parotid gland
Mumps virus
________ is common
_______________ can occur
orchitis oophoritis occurs in (children or adults?)
meningitis
encephalitis
adults
Single mumps serotype has shared antigens with ???
paraflu type 1
Mumps:Pathogenesis
infection by _________ leading to __________ that spreads to _______ and ________ causing _______ and cell death
droplet
viremia
glands ; nervous tissue
inflammation
Mumps:Epidemiology
worldwide
endemic in (urban or rural?) areas
intermittant in (urban or rural?) areas
epidemic 2-7 years
peak incidence Jan-May
urban
rural areas
Mumps:Diagnosis
TYPICAL is by _________ diagnosis
ATYPICAL: ________ virus and viral antigen in ________ or ________. Detect specific Ig___ and Detect rising titer of Ig____
clinical
isolate
saliva : CSF
IgM ;of IgG
Defenses against Mumps
________
__________ immunity
__________ immunity
lifelong protection
Interferon
humoral immunity
cell mediated immunity
Mumps:Control
____________ vaccine
long term protection
reinfections (can or can not?) occur
live attentuated
Can
Measles: Clinical manifestions
coryza, __________ , ______ rash ______________ rash ____ days later
conjunctivitis
fever rash
maculopapular
1-3
Measles: Complications
________ , ______ , ________
SSPE (___________________________)-rare
otitis ; pneumonia
encephalitis
subacute sclerosing panencephalitis
Measles: Pathogenesis
________ occurs
multiples in cells of :
_________ system, _________ system, ——— and _______
viremia
lymphatic ; respiratory
skin ; brain
Measles:Host Defenses
————
———— immunity
———— immunity
Life long protection
Interferon
Humoral immunity
Cell mediated immunity
Measles: Control
Active vaccination
______________ virus vaccine
long lasting protection
Passive immunity
measles _____________
Live attentuated virus
hyperimmunoglobulin
WHO MeaslesVaccination Strategy
”catch-up” everyone aged _______ years
”keep-up” ____% of children at age _________
”follow-up” ____________
1-14 years
90% ; 12 months
3-5 years
RSV:Clinical manifestions
_____________________ infection
frequent in ________
significant in __________
upper & lower respiratory tract
young children
elderly
RSV: Pathogenesis
infection by __________ with ________
infects _________________ of respiratory mucosa
localized
A___________ D__________ C___________
direct contact ; droplets
ciliated epithelium
Antibody Dependent Cytotoxicity
RSV: Host Defenses
_________
cell mediated immunity
Humoral immunity
___________ immunity ( _______) reinfection possible
interferon
Secretory immunity
sIgA
RSV: Epidemiology
worldwide
_________ climates
epidemic winter and early spring infants & young children
temperate
RSV: Control
_______ vaccine
_________ as aerosol
___________ patients in hospitals
no
ribavrin
isolate
