Sexually Transmitted Viral Diseases_HPV/HBV/HCV

Question 1

The Hepatitis B Virus (HBV)

HBV is a mostly ______-stranded _____ virus in the _________ family.

HBV causes ______ in human.

The HBV genome has ______ genes

Answer 1

double-stranded ; DNA

Hepadnaviridae family.

hepatitis ; four genes

Question 2

The Hepatitis B Virus (HBV)

The HBV genome has four genes: ____,______,________, and _________ that respectively encode the viral __________,__________,__________ (which is processed to viral ______) and ________

Answer 2

pol, env, pre-core and X

DNA-polymerase
envelope protein
pre-core protein ; capsid
protein X.

Question 3

HBV

The function of protein X is ______ but it may be involved in the ________ of host cell genes and the development of _______.

Answer 3

activation

cancer.

Question 4

Consequences of HBV Infection

HBV causes ____________ hepatitis.

The chances of becoming chronically infected depends upon ______.

Answer 4

acute and chronic hepatitis.

age.

Question 5

Consequences of HBV infection

The chances of becoming chronically infected depends upon age.
– About 90% of infected ______ and 50% of infected __________ will become chronically infected.
– In contrast, only about 5% to 10% of _____________ ___________ infected with HBV develop chronic hepatitis B.

Answer 5

Neonates

Young children

Immunocompetent adults

Question 6

Hepatocellular carcinoma

cancer that arises from ________, the major cell type of the liver.

Hepatocellular carcinoma is one of the (minor or major?) cancer killers.

It affects patients with _________ disease who have established _____ ,and currently is the most frequent cause of death in these patients.

Answer 6

hepatocytes ; major

chronic liver disease

cirrhosis

Question 7

Hepatocellular carcinoma

The main risk factors for its development are _______ and _________ virus infection, _________ and _______ intake.

Answer 7

hepatitis B and C virus infection

alcoholism and aflatoxin intake.

Question 8

HEPATITIS C VIRUS

A/An (naked or enveloped?) ————- RNA virus

Causes ____________ hepatitis

Most implicated in the development of ________ and liver ________

Anti-HCV antibodies develops _________ after exposure

_______ donors also screened for HCV

Diagnosis same as HBV

Answer 8

enveloped ; icosahedral

both acute and chronic hepatitis

carcinoma ; liver cirrhosis

months ; Blood

Question 9

HEPATITIS C VIRUS

______ vaccine against HCV

(Low or High?) rate of treatment failure

Treatment with antiviral agent (_______)
Belongs to the ______virus family

Answer 9

No; High ; Ribavirin

Flavivirus