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Hematology, oncology > Terminology > Flashcards

Terminology Flashcards

1
Q

“Definitive”

A

Treatment with plan for a cure

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2
Q

Terminology for someone discontinuing treatment

A

“coming off of treatment”

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3
Q

Term for real progression

A

“true progression”

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4
Q

Term for drug approved regardless of PD-L1 level

A

PD-L1 agnostic

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5
Q

What does “y” in pathologic staging denote

A

Treated neoadjuvantly

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6
Q

Poor response to treatment term

A

minimal treatment effect

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7
Q

time until treatment is started

A

time to treatment

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8
Q

patient hasn’t been started on treatment

A

“treatment naive”

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9
Q

TTFT is

A

Time to first treatment

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10
Q

Small number of cells with microdeletion on FISH referred to as…

A

Small clone

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11
Q

Terminology to describe indolent disease

A

“favorable biology”

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12
Q

Progression on chemotherapy referred to as

A

primary progression

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13
Q

Fixed duration therapy

A

Time limited therapy

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14
Q

“line agnostic”

A

Can you use in any lines

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15
Q

giving someone the same drug

A

Retreat

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16
Q

Term for concerning lymph node

A

Pathologic appearing

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17
Q

Treatment break

A

Chemo holiday

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18
Q

Trial that was funded by pharmaceutical company

A

“industry sponsored”

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19
Q

DSS

A

disease specific survival

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20
Q

late relapse

A

distant relapse

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21
Q

Local recurrence term

A

loco-regional recurrence

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22
Q

LVSI

A

lymphovascular space invasion

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23
Q

What is “clinical benefit rate” usually defined as?

A

Response + stable disease

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24
Q

Desperation oncology

A

self explanatory

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25
Q

2 primaries diagnosed at same time (developing at same time) are typically referred to as

A

Synchronous primaries

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26
Q

If it’s not de novo metastatic then it’s

A

Metachronous metastatic

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27
Q

Rate of disease progression referred to as

A

Disease tempo

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28
Q

Term for radiation therapy target

A

Target Volume

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29
Q

Asthenia meaning

A

weakness

30
Q

Fanconi anemia inheritance

A

Autosomal recessive (mostly) can be x-linked

31
Q

Fanconi anemia physical exam findings

A

thumb hypoplasia + short stature + a few others

32
Q

Fanconi anemia hallmark pathophys

A

Chromosomal instability/fragility (leading to cell death of hepatopoietic stem cells and progressive bone marrow failure)

33
Q

Fanconi anemia lab features

A

macrocytic anemia
Pancytopenia
Bone marrow failure by age 40
*increased risk of solid tumors

34
Q

Fanconi anemia treatment

A

Transplant
*careful planned conditioning regimen given chromosomal instability

35
Q

Dyskeratosis congenita hallmark pathophys

A

Telomere biology disorder

36
Q

Dyskeratosis congenita classic features

A
  • abnormal skin pigmentation
  • nail dystrophy
  • leukoplakia
37
Q

Dyskeratosis congenita other clinical features

A
  • pulmonary fibrosis
  • cirrhosis
  • malignancies
  • bone marrow failure by age 30
38
Q

Dyskeratosis congenita testing

A

telomere length testing –

39
Q

Dyskeratosis congenita treatment

A

anabolic steroids (short term)
HSCT

40
Q

Schwachman-Diamond syndrome inheritance

A

autosomal recessive

41
Q

Schwachman-Diamond syndrome clinical features

A
  • pancreatic insufficiency
  • BM dysfunction
  • neutropenia
  • MDS/AML in young adults, usually males
42
Q

Schwachman-Diamond mutation

A

SBDS

43
Q

Schwachman-Diamond syndrome treatment

A

G-CSF (assuming no myeloid malignancy)
Allo SCT for BM issues

44
Q

Diamond blackfan anemia inheritance

A

autosomal dominant

45
Q

Diamond blackfan anemia clinical features

A
  • infant with red cell aplasia
  • increased cancer risk
46
Q

Diamond blackfan anemia treatment

A
  • steroids
  • transfusions
  • HSCT
47
Q

Congenital dyserythropoetic anemia pathophys

A

ineffective erythropoeisis leading to anemia

48
Q

Congenital dyserythropoetic anemia inheritance

A

autosomal recessive

49
Q

Congenital dyserythropoetic anemia I clinical features

A
  • childhood
  • hemolytic anemia
  • binucleated erythroblasts
50
Q

Cyclic neutropenia treatment

A

G-CSF

51
Q

Severe congenital neutropenia clinical features

A
  • severe ANC in childhood + fevers and severe infections
52
Q

Severe congenital neutropenia gene association

A

ELANE mutation

53
Q

Thrombocytopenia with absent radi (TAR) clinical features

A
  • hypomegakaryoctyic thrombocytopenia + bilateral radial aplasia (but normal thumb)
  • hemorrhagic manifestations at birth
  • transient (improves after infancy)
54
Q

WHIM syndrome stands for

A

warts
hypogammaglobulinemia
infections
myelokathexis

55
Q

WHIM syndrome inheritance

A

autosomal dominant

56
Q

GATA2 deficiency inheritance

A

autosomal dominant

57
Q

GATA2 deficiency clinical features

A

very high risk of MDS

58
Q

How is cure typically defined?

A

5 year recurrence free survival

59
Q

Oncotype and other molecular profiling tools referred to as

A

Genomic classifiers

60
Q

Walsh quote for what to do with the absence of data

A

Absence of evidence is not the same thing as evidence of absence

61
Q

Basic term for resistant disease

A

Subclone

62
Q

“Basic science rationale for a clinical trial”

A

Preclinical rationale

63
Q

Term for tumor arising within a pulmonary bronchus

A

endobronchial

64
Q

Term for describing molecular profile of a tumor

A

Mutational status

65
Q

Remission

A

Synonymous with partial or complete response

66
Q

Median time to response in solid tumors

A

6-8 weeks

67
Q

PET response terminology

A

partial or complete metabolic response

68
Q

Term for chemotherapy that increases risk for hematologic malignancy

A

Leukemogenic

69
Q

Using a drug that is not currently approved is referred to as

A

Off-label use

70
Q

Term to use for something that is positive on PET

A

PET avid

71
Q

What does myeloablative chemotherapy refer to?

A

High dose chemotherapy, ie conditioning regimens before transplant to wipe out marrow

72
Q

Using imaging to alter treatment midway through

A

Response adapted therapy

Hematology, oncology (218 decks)

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