Protein S deficiency Flashcards
1
Q
Function of protein S
A
serves as a cofactor for activated protein C, which inactivates procoagulant factors Va and VIIIa, reducing thrombin generation
2
Q
Causes of false positives in protein S deficiency
A
Liver disease → Acute thrombosis → Pregnancy or estrogen treatment → ***Any comorbid illness that causes an acute phase response can lower the level of free protein S → Anticoagulants: Warfarin, NOAC treatment
