Prophylaxis

Question 1

Acyclovir dosing

Answer 1

400 mg PO BID

Question 2

When PCP prophylaxis is indicated

Answer 2

Allo transplants
Some auto transplants
Some induction regimens for ALL

Question 3

when HSV ppx is indicated

Answer 3

• Induction chemo for acute leukemia

- Allo HCT

Question 4

Patients who need VZV ppx

Answer 4

HCT recipients who are seropositive for VZV

Question 5

Preferred agents for VZV ppx

Answer 5

Valacyclovir

Question 6

Frequency of reactivation of CMV

Answer 6

Rare in patients with chemo-induced neutropenia

Question 7

Problem with patients with history of HBV

Answer 7

At high risk of reactivation with a flare of hepatitis

Question 8

What fluconazole is used for

Answer 8

TARGETED candida primary

Question 9

What voriconazole and posiconazole target

Answer 9

candida + molds

Question 10

when are patients at high risk for candida

Answer 10

• oral and/or GI mucositis

- duration of neutropenia greater than 7 days

Question 11

When voriconazole and posiconazole are used instead of fluconazole

Answer 11

Prolonged severe neutropenia (this is when patients are at risk of invasive mold infections)