Acute lymphoblastic leukemia (T-cell ALL)

Question 1

Definition

Answer 1

greater than 25% blasts in marrow

Question 2

management in general vs b-cell ALL

Answer 2

same regimens

Question 3

Clinical difference of hyperleukocytosis in t cell all vs b cell

Answer 3

Does not have same poor prognostic importance in t cell as in b cell

Question 4

Location of involvement that is favorable risk

Answer 4

Mediastinal

Question 5

Poor risk cytogenetics

Answer 5

• hypodiploidy
• KMT2A rearranged
• t(v;14q23)-IgH
• complex karyotype
• Ph-like
• intrachromosomal amplification of chromosome 21
• t(17;19)
• alterations of AKZF1

Question 6

Broad classification of ALL

Answer 6

• precursor B-ALL
• mature B-ALL
• T-ALL

Question 7

Options for relapsed

Answer 7

Nelarabine

Question 8

what is T-cell lymphoblastic lymphoma (T-LBL)?

Answer 8

• considered same disease as T-ALL but differs in extent of bone marrow infiltration

Question 9

Maintenance therapy for T-cell ALL and T-LBL

Answer 9

POMP x2-3 years (confirm)