High yield ITE Flashcards
Sarcoma imaging - role of PET + MRI
- typically MRI of extremity
- PET not done routinely, useful for high-grade sarcomas to differentiate from benign soft tissue tumors
Staging workup of sarcoma of extremities, trunk, and head and neck
MRI
NHT with demonstrated MFS benefit for BCR
enzalutamide
Staging workup of sarcoma
- MRI of extremity
- CT chest (propensity for lung mets)
- CT abdomen pelvis for certain histologies but not done routinely (round cell, myxodi)
More aggressive papillary thyroid cancer variant
Tall cell variant
1) phyllodes tumor management 2) Margin requirement
Primary surgery
Review path
Need margins of at least 1 cm
Osteoradionecrosis risk factors in head and neck
- oral cavity primary
- smoking
- reirradiation (but only slightly higher)
Drugs targeting ROS1
- Crizotinib
- Lorlatinib
*Entrectinib - Repotrectinib
Serologies positive in LEMS
Voltage gated calcium channel antibody test
Paraneoplastic neurologic disorder associated with small cell
LEMS
LEMS presentation
- proximal muscle weakness
- ptosis, cranial nerve involvement
- respiratory failure later on
- autonomic dysfunction (dry mouth)
Lymphoma that is CD4, CD56, CD123 positive
Blastic plasmacytoid dendritic cell neoplasm
Drug approved for blastic plasmacytoid dendritic cell neoplasm
tagraxofusp
First line for metastatic ovarian cancer
IF able to resect disease, maximal debulking surgery
IF nonsurgical candidate, neoadjuvant conversion systemic therapy
Carbo/taxol q3 weeks to max 6 cycles (but no real max per Zweizig)
CDH1 associated malignancies
- lobular breast cancer
- diffuse gastric cancer
CHEK2 associated malignancies
breast cancer (particularly ER-positive breast cancers), male breast cancer, stomach, prostate, kidney, leukemia, plasma cell neoplasms, thyroid cancer, and sarcoma
tp53 disease associations
Soft tissue sarcomas
●Osteosarcomas
●Adrenocortical carcinomas
●Central nervous system tumors (mainly glial, choroid plexus, and medulloblastoma)
●Breast cancers in young females (≤30 years)
●Acute leukemias or myelodysplastic syndromes (MDS), often following treatment for one of the above solid tumors
HPV oropharyngeal clinical features in terms of size and nodal involvement
HPV tumors are typically smaller but have increased risk of advanced cervical lymphadenopath
Prevalence of triple negative myelofibrosis
8-10 percent
Risk of progression to overt myeloma with high risk smoldering at 2 years
25%
CLL RAI Stage I
lymphocytosis + enlarged lymph nodes
CLL RAI Stage II
Lymphocytosis + enlarged liver or spleen with or without lymphadenopathy
CLL Rai stage III
Lymphocytosis + anemia (hgb <11) with or without enlarged livers, spleen, or lymph nodes
CLL Rai stage IV
lymphocytosis + thrombocytopenia (plt <100K) with or without anemia or enlarged liver, spleen, or lymph nodes
CLL RAI Stage 0
Lymphocytosis alone (no cytopenias or lymphadenopathy)
11q22.3 is the site of what gene
ATM
Loss of which gene is typical of CLL
ATM (disurption of DNA repair pathways is one of the common contributors to CLL pathophysiology)
Clinical features of hepatosplenic T cell lymphoma
Young male in 30s + hepatomegaly + no lymphadenopathy + aggressive phenotype
Defining cytogenetic abnormality of hepatosplenic t cell lymphoma
Isochromosome 7q