T cell lymphoproliferative disorders

Question 1

Clinical features of T-Large granular lymphocyte leukemia

Answer 1

• unexplained, chronic elevation in large granular lymphocytes in the peripheral blood (chronic lymphoproliferative disorder)
• commonly associated with RA
• splenomegaly

Question 2

Preferred initial therapy for CD30 positive peripheral T cell lymphomas

Answer 2

Brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone (A-CHP)