Miscellaneous

Question 1

NPI number

Answer 1

1255835724

Question 2

lab profile of vitamin k deficiency + common clinical scenario

Answer 2

PT + INR prolonged + PTT normal or mildly prolonged + patient on oral antibiotics with poor oral intake

Question 3

normal spleen size

Answer 3

12-14 cm. Significant variability depending on age and weight.

Question 4

What is posttransplant lymphoproliferative disorder (PTLD)?

Answer 4

• uncontrolled proliferation of B cell lymphocytes latently infected with Epstein-Barr virus (EBV). In immunocompetent patients, Epstein-Barr virus can cause infectious mononucleosis in adolescents, which is otherwise asymptomatic in children during their childhood. However, in immunosuppressed transplant patients, the lack of T-cell immunosurveillance can lead to the proliferation of these EBV-infected B-lymphocytes.

Question 5

which transplants are associated with a higher incidence of PTLD?

Answer 5

solid organ, particularly those requiring higher degrees of immunosuppression (ie heart and lung)

Question 6

What is the function of BCL2?

Answer 6

Antiapoptotic gene that encodes one of the proteins involved in regulating cell death

Question 7

Why is MSI correlated to response to immunotherapy

Answer 7

When you have mutated genes, you have more mutated antigens promoting an immune response

Question 8

Concept of tumor mutational burden

Answer 8

quantifies mutational burden, higher burden suggests better response to immunotherapy

Question 9

Concept of “tumor agnostic” therapies

Answer 9

Tumour-agnostic therapies target specific genomic anomalies or molecular features regardless of tumour site of origin.

Question 10

signet ring cells origin

Answer 10

GI tract origin

Question 11

which service does excisional lymph node biopsies

Answer 11

general surgery

Question 12

what does leukemoid reaction mean?

Answer 12

General term for a WBC greater than >50,000/microL from causes other than leukemia, with majority of cells being mature neutrophils, often accompanied by increased numbers of bands, metamyelocytes, and/or myelocytes. Not specific physiologic reaction, just terminology.

Question 13

What is Castleman disease?

Answer 13

group of uncommon lymphoproliferative disorders characterized by lymph node enlargement, characteristic features on microscopic analysis of enlarged lymph node tissue, and a range of symptoms and clinical findings

Question 14

Basic categories of Karnofsky performance status

Answer 14

80 or higher = able to carry on normal activity and to work
50 -80 = requires assistance with ADLs
0 - 40 = Unable to care for self, requires equivalent of institutional or hospital care

Question 15

Supplements that increase bleeding risk

Answer 15

• ginkgo
• ginseng
• saw palmetto

Question 16

RFI means

Answer 16

recurrence free interval

Question 17

what is an implant

Answer 17

A nodule of a malignant tumor that develops at a site in a body cavity at a distance from the initial site of cancer

Question 18

how much iron is in 1 unit of PRBC’s?

Answer 18

200-250 mg

Question 19

What is leukoerythroblastosis? Cause?

Answer 19

• presence of nucleated red cells and immature white cells in peripheral blood
• marrow replacement, usually due to fibrosis that may be idiopathic (eg, primary myelofibrosis) or reactive to conditions such as metastatic cancer.

Question 20

Checkpoint inhibitor toxicities for which you would never rechallenge

Answer 20

1) encephalitis
2) demyelinating neuropathy
3) cardiotoxicity

Question 21

What is an abnormal size for a lymph node?

Answer 21

> 1 cm in diameter

Question 22

How do solid tumor brains met typically appear on MRI

Answer 22

round subcortical lesions

Question 23

Physiology explaining why response to IO persists

Answer 23

Animal models have shown that ICI administration leads to expansion of tumor-specific T cells which persist long after the ICI has been stopped

Question 24

What research modality determines if dose reduction is needed for organ dysfunction?

Answer 24

PK studies