Marginal zone lymphoma

Question 1

Classification of marginal zone lymphoma

Answer 1

Nodal
Extranodal (MALT)
Splenic

Question 2

Clinical behavior of marginal zone lymphoma

Answer 2

indolent

Question 3

Pathophys

Answer 3

Antigen-driven disease (h pylori, borrelia burgdorferi, Sjogren’s disease)

Question 4

Treatment of gastric MALT

Answer 4

IF h pylori positive – treat h pylori

NEVER surgery anymore

Question 5

Caveat about h pylori positive gastric MALT treatment

Answer 5

Response may take a long time (up to 1 year)

Question 6

Treatment of extranodal marginal zone lymphoma

Answer 6

Localized treatment (radiation)

Question 7

Splenic marginal zone lymphoma clinical features

Answer 7

splenomegaly + cytopenias + often NO adenopathy

Question 8

Splenic marginal zone lymphoma treatment

Answer 8

Single agent rituximab (used to be splenectomy)

Question 9

What is leukemic phase?

Answer 9

A finding of unusual high amounts of lymphocytes in the peripheral blood (lymphocytosis) suggesting that the lymphoma cells are in the blood in high concentrations.