Cytokine release syndrome Flashcards
1
Q
Severe CRS management
A
tocilizumab + steroid
2
Q
When it happens
A
1) CAR-T cell therapy
2) Haplo transplants
3) Therapeutic antibodies (BiTE antibody therapy)
3
Q
Presentation of mild CRS
A
- flu like illness
- Fever (by definition) at onset
- fatigue
- HA
- rash
- diarrhea
- arthralgia
- myalgia
4
Q
Presentation of severe CRS
A
- Fever (by definition) at onset
- hypotension
- vascular leakage leading to pulmonary edema and respiratory distress
- renal failure
- cardiac dysfunction
- neurotoxicty
- multiorgan system failure
5
Q
Clinical features of severe CRS
A
elevated inflammatory markers + fever + multiorgan failure + absence of positive infectious workup + in setting of transplant, CAR-T, or immune therapy
6
Q
CRS basic pathophys
A
systemic inflammatory syndrome resulting from immune dysregulation
7
Q
treatment of mild CRS
A
symptomatic treatment with antihistamines, antipyretics, intravenous fluids, and close monitoring
8
Q
When do neuropsych findings develop?
A
**2-4 after onset of severe CRS
