CNS Lymphoma Flashcards
Preferred first line
High-dose systemic MTX-based ***combination chemotherapy w/ rituximab
Optimal consolidation therapy
Not established
Consolidation options
- High dose chemo with autologous HCT rescue
- WBRT
- nonmyeloablative chemo
General prognosis
Most patients don’t achieve long-term disease control or survival with induction chemo alone
Response assessment
MRI brain
Term for Lymphoma involvement of retina on slit lamp
primary intraocular lymphoma (primary CNS lymphoma presenting in eye)
Why do you need high dose MTX for CNS lymphoma?
High doses are needed to overcome the blood-brain barrier and achieve therapeutic levels
what is high dose MTX defined as
greater than 3.5
Why is MTX commonly combined with other agents for primary CNS lymphoma?
Enhance tumor kill
Management of CNS lymphoma patient who is not a candidate for systemic chemotherapy
Palliative WBRT
Only established risk factor for primary CNS lymphoma
Immunodeficiency
Gold standard for CNS lymphoma diagnosis
Slit-lamp evaluation and funduscopic examination
How do you diagnose CNS lymphoma?
LP w/ CSF and cytology
IF CSF cytology negative AND tissue safely obtainable, biopsy (Tissue sampling mandatory for diagnosis)
