Research

Question 1

What are the pembro trials typically referred to as?

Answer 1

KEYNOTE

Question 2

What are the nivo trials typically referred to as?

Answer 2

Checkmate

Question 3

What is EFS?

Answer 3

Event free survival

Question 4

Partial response definition

Answer 4

Shrinkage of at least 30%

Question 5

TTP in clinical trials stands for

Answer 5

time to progression

Question 6

RFS

Answer 6

relapse free survival

Question 7

what is considered progression in PFS

Answer 7

• New tumor, death, OR increase of more than 20% from smallest size.

Question 8

PITFALL of RECIST

Answer 8

One dimension

Question 9

What does DFS mean

Answer 9

Also a composite. Time until death OR recurrence of cancer.

Question 10

What is the concept of “intention to treat”? Why is it used?

Answer 10

You should judge a drug based on all patients allocated to get it, irrespective of whether or not they received it. Because it may take a long time to give the drug and sickest may die in the meantime, distorting the benefit

Question 11

Post hoc analysis result should be interpreted as?

Answer 11

Hypothesis generating only