Emergencies

Question 1

Management of leukostasis in leukemia

Answer 1

Aggressive IV hydration
Cytoreduction with hydroxyurea
Leukophoresis

Question 2

medical emergency common in APL

Answer 2

differentiation syndrome

Question 3

RF’s for differentiation syndrome

Answer 3

ATRA, arsenic

Question 4

signs/symptoms of differentiation syndrome

Answer 4

fever, weight gain, edema, dyspnea, hypoxia, worsening renal function, opacities on CXR, pleural/pericardial effusions, hypotension

Question 5

treatment of differentiation syndrome

Answer 5

Dexamethasone 10 mg BID
IF severe symptoms →
stop ATRA
Start cytotoxic chemo (if not already done)