ovarian cancer Flashcards
ovarian cancer mortality
high (most people present late stage due to nonspecific presentation)
BRCA pattern of inheritance
autosomal dominant
ovarian cancer and chemosensitivity
extremely chemosensitive, so some people can be cured if caught early
ovarian cancer and relapse
very high, advanced stage frequently recur
what is homologous recombination?
primary mechanism of double strand DNA break repair
Prognosticators in ovarian cancer
homologous recombination deficiency
first line mgmt of ovarian cancer
some combination of chemo + surgery
PARP inhibitor effect on PFS
dramatic, huge survival benefit, so all these patients should get BRCA testing
VEGF mechanism
angiogenesis
meaning of term “Platinum-refractory”
disease progression during first line platinum treatment
PLD stands for
pegylated liposomal doxorubicin
immunotherapy and ovarian cancer in general
very disappointing
Most common grade 3/4 AE of olaparib
anemia
most common SE’s of olaparib
nausea, fatigue, vomiting
Most common grade 3/4 AE of rucaparib
thrombocytopenia/liver toxicity
