ovarian cancer Flashcards
ovarian cancer mortality
high (most people present late stage due to nonspecific presentation)
BRCA pattern of inheritance
autosomal dominant
ovarian cancer and chemosensitivity
extremely chemosensitive, so some people can be cured if caught early
ovarian cancer and relapse
very high, advanced stage frequently recur
what is homologous recombination?
primary mechanism of double strand DNA break repair
Prognosticators in ovarian cancer
homologous recombination deficiency
first line mgmt of ovarian cancer
some combination of chemo + surgery
PARP inhibitor effect on PFS
dramatic, huge survival benefit, so all these patients should get BRCA testing
VEGF mechanism
angiogenesis
meaning of term “Platinum-refractory”
disease progression during first line platinum treatment
PLD stands for
pegylated liposomal doxorubicin
immunotherapy and ovarian cancer in general
very disappointing
Most common grade 3/4 AE of olaparib
anemia
most common SE’s of olaparib
nausea, fatigue, vomiting
Most common grade 3/4 AE of rucaparib
thrombocytopenia/liver toxicity
PARP inhibitor cost and tolerance
hugely expensive + relatively well tolerated
game changer class of drugs in ovarian cancer
PARP inhibitors
tumor markers and relevance
can be important but nonspecific
front line for advanced ovarian cancer
IV carbo/taxol q21 days
next step after palpation of an adnexal mass
Paracentesis with cytology (high yield in ovarian cancer)
Indication for BRCA testing in ovarian cancer
All women with ovarian cancer need BRCA testing, regardless of age of onset, family history, or ancestry
Surveillance
routine imaging not recommended after initial treatment
