Burkitt lymphoma

Question 1

Induction therapy for Burkitt’s? CNS prophylaxis required?

Answer 1

R-HyperCVAD + CNS prophylaxis

Question 2

R-Hyper-CVAD contains? What does hyper refer to?

Answer 2

rituximab, hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone, alternating with MTX and cytarabine. Intrathecal MTX gives similar outcomes.

Question 3

what is a “double hit” lymphoma?

Answer 3

• MYC translocation with an additional translocation

- Intermediate histologic features between DLBCL and BL

Question 4

characteristic translocation

Answer 4

8;14

Question 5

what are the b cell markers

Answer 5

CD19, CD20, CD22

Question 6

Ki67 in burkitt’s

Answer 6

almost always 100%

Question 7

malignancy that appears histologically very similar to Burkitt’s

Answer 7

double-hit DLBCL (can be very difficult to differentiate)

Question 8

explanation for starry sky pattern on blood smear

Answer 8

macrophages that contain dead tumor cells

Question 9

what are the germinal center-associated markers

Answer 9

CD10 and BCL6