Neuroendocrine tumors

Question 1

First line for low grade unresectable NET

Answer 1

Typically somatostatin analogue (octreotide 30 mg q4 weeks) if functional, observation otherwise

Question 2

Management of high grade NET

Answer 2

Systemic therapy w/ small cell regimen (behaves like small cell)

Question 3

WHO grading is based on

Answer 3

KI-67 primarily

Question 4

typical regimen for high grade

Answer 4

Platinum based chemo (cis etoposide)

Question 5

second line for gastrointestinal NET

Answer 5

PRRT (preferred)
everolimus

Question 6

histology of NETs

Answer 6

They are highly vascularized tumors, hence VEGF

Question 7

Preferred first line for NETs

Answer 7

surgery

Question 8

Subtype of low grade that is much more chemo sensitive

Answer 8

pancreatic - PNET (CONFIRM)

Question 9

SSAs means

Answer 9

somatostatin analogues

Question 10

Timing of SSAs and Lutetium dotatate

Answer 10

Hold 4-6 weeks before but can be given 24h after

Question 11

Use of amino acids solutions for PRRT + primary SE

Answer 11

• prevent nephrotoxicity but cause a lot of nausea

Question 12

First line for localized PNET

Answer 12

surgery