Drugs 3

Question 1

What are the anthracyclines?

Answer 1

daunorubicin, doxorubicin, epirubicin, idarubicin

Question 2

What are the camptothecins?

Answer 2

Topoisomerase inhibitors

Question 3

What is Folfirinox?

Answer 3

FOLFOX + irinotecan

Question 4

Oxalaplatin SE profile

Answer 4

sensory neuropathy, myelosuppression, elevated liver enzymes, emesis, diarrhea

Question 5

BEAM regimen

Answer 5

carmustine (BCNU), etoposide, aracytin and melphalan

Question 6

Neulasta SE profile

Answer 6

Splenomegaly, splenic rupture, bone pain, extremity pain, ARDS (has been described).

Question 7

General risk of cardiomyopathy with HER2 inhibitors

Answer 7

Most of the incidence was in trials in which HER2 inhibitors were combined with anthracyclines, so risk of cardiomyopathy with HER2 inhibitors is actually fairly low

Question 8

Platinum doublet

Answer 8

• Typically refers to cornerstone of treatment for advanced NSCLC
• platinum compound (cisplatin or carboplatin) + one third generation agent (mainly vinorelbine, gemcitabine or taxanes),

Question 9

KRAS and cetuximab

Answer 9

Cetuximab is approved for KRAS wildtype tumors

Question 10

Reported late SE’s of chemoRT for rectal cancer

Answer 10

increased frequency and urgency of defecation, chronic perianal dermatitis, dyspareunia, impotence

Question 11

Palbociclib trade name

Answer 11

Ibrance

Question 12

Durvalumab trade name

Answer 12

Imfinzi

Question 13

Atezolizumab trade name

Answer 13

Tecentriq

Question 14

What is the mechanism of action of fluoropyrimidines?

Answer 14

Antimetabolites

Question 15

What are the fluoropyrimidines?

Answer 15

capecitabine, floxuridine, and fluorouracil (5-FU)

Question 16

Tremelimumab mechanism

Answer 16

CTLA-4