Plasmacytoma

Question 1

Definition

Answer 1

Solitary plasmacytoma = a single tumor by definition + no other features of MM
- multiple plasmacytomas = multiple myeloma

Question 2

Location (generally speaking)

Answer 2

• Most frequently occur in bone (plasmacytoma of bone)

- Can also be found in soft tissues

Question 3

Term for plasmacytoma of soft tissue

Answer 3

extramedullary plasmacytoma

Question 4

Clinical Presentation

Answer 4

Symptoms related to location of mass (commonly involve upper respiratory tract)

Question 5

Diagnostic criteria

Answer 5

Biopsy-proven extramedullary tumor with clonal plasma cell population 
AND
PET/CT without lytic lesions
AND
no CRAB symptoms
AND
BMB without clonal plasma cells

Question 6

Treatment of choice for solitary plasmacytoma

Answer 6

RT over 4 week period (unless complete surgical resection performed as part of diagnosis)

Question 7

Goal of treatment

Answer 7

curative

Question 8

Role for adjuvant chemo?

Answer 8

NOne (no effect on DFS or relapse rate)

Question 9

Sequela

Answer 9

10-15% go on to develop MM

Question 10

Prognosis

Answer 10

Very few recur, survival rates are good

Question 11

Role for bisphosphonates?

Answer 11

Not recommended, except in setting of underlying osteopena

Question 12

Plasmacytoma subtypes

Answer 12

1) Plasmacytoma of bone
2) Extramedullary Plasmacytoma
3) Multiple plasmacytomas