Clonal hematopoiesis of indeterminate potential (CHIP)

Question 1

Defining features

Answer 1

• single clonal mutation (DNMT3A, TET2, ASXL1) at low variant allele frequency
• people, generally older people, have clonal mutations but no hematologic disorder

Question 2

What to think when you see a clonal mutation at low frequency

Answer 2

• whether it is a driver mutation

Question 3

Classic CHIP mutations

Answer 3

DNMT3A
TET2
ASXL1