Hypereosinophilic syndromes (HES) Flashcards
1
Q
Diagnostic criteria
A
1) greater than 1500 eosinophils for at least 6 months
2) no other cause of eosinophilia
3) evidence of end organ involvement
2
Q
Mortality due to what?
A
neurologic and endomycardial involvement
3
Q
organ systems most commonly affected
A
skin, lungs, GI tract, heart, nervous system
4
Q
most common mutation
A
FIP1L1/PDGFRA
5
Q
treatment of patients harboring FIP1L1/PDGFRA
A
imatinib
