Factor V Leiden

Question 1

Pathophys

Answer 1

• results from a point mutation in the F5 gene, which encodes the factor V protein in the coagulation cascade. FVL renders factor V (both the activated and inactive forms) insensitive to activated protein C (aPC), a natural anticoagulant. Thus, pts are at increased risk of VTE.

Question 2

Prevalence in US population

penetrance

Answer 2

(5%)

Variable. Manh people never have a VTE

Question 3

Does presence of FVL affect duration of anticoagulation?

Answer 3

• not thought to increase risk for recurrent VTE, thus same duration of anticoagulation

Question 4

Management

Answer 4

Same as VTE management in anyone else

Question 5

Anticoagulant for FVL patients with VTE

Answer 5

Can use DOACs