Hemolytic anemia Flashcards
1
Q
Workup of hemolytic anemia (once diagnosed)
A
1) Peripheral smear (if chronic or FH to rule out congenital causes)
2) Coombs test
2
Q
treatment of warm AIHA + dosing
A
(Steroids until anemia resolves, then taper)
Prednisone 1-2 mg/kg/day
continue prednisone until Hgb >10
taper prednisone over 4-6 months
IF pred not effective within 2-3 weeks → add Rituximab
3
Q
causes of warm AIHA
A
primary/idiopathic (50%) →
Medications (penicillins, cephalosporins) →
CVID →
4
Q
Intramedullary hemolysis refers to
A
RBC hemolysis in the marrow prior to release into circulation
5
Q
Intramedullary hemolysis occurs in
A
1) Pernicious anemia
2) Thalassemia major
6
Q
Intrinsic vs. extrinsic hemolysis refers to
A
Intrinsic = cause related to RBC itself (defects in RBC metabolism production, or membrane production) Extrinsic = external factors
7
Q
Other causes of low haptoglobin
A
cirrhosis or recent transfusion
