Pure red cell aplasia

Question 1

lab features

Answer 1

• severe normocytic anemia
• reticulocytopenia
• absence of erythroblasts with otherwise normal bone marrow

Question 2

causes of acquired PRCA

Answer 2

• parvovirus
• LGL
• thymoma
• autoimmune disease
• medications
• allogeneic hematopoietic stem cell transplant (recipient isohemagglutinins interfere with donor erythroid engraftment)