Coagulation/clotting cascade

Question 1

First step in hemostasis

Answer 1

Platelet activation and platelet plug formation

Question 2

Basic pathophys defect in Bernard-soulier

Answer 2

Defect in platelet adhesion

Question 3

Basic pathophys defect in Glanzmann thrombosthenia

Answer 3

Defect in platelet aggregation

Question 4

Natural anticoagulant pathways

Answer 4

• antithrombin
• protein C
• tissue factor-pathway inhibitor

Question 5

what is dilutional coagulopathy

Answer 5

• alterations in clotting from receiving a large volume of IV fluids or unbalanced component blood administration (10 units of PRBCs without other blood products)

Question 6

What is massive transfusion

Answer 6

• Replacement of a patient’s blood volume in less than 24 hours (takes about 10 units)

Question 7

trade named for four factor PCC

Answer 7

Kcentra

Question 8

Lovenox reversal agent + caveat

Answer 8

protamine sulfate (does not work that well)

Question 9

Lovenox half life

Answer 9

4 hours

Question 10

what is the function of factor Xa

Answer 10

Catalyzes the conversion of prothrombin to thrombin (enzyme responsible for fibrin clot formation)

Question 11

direct oral anticoagulant with least renal excretion

Answer 11

eliquis

Question 12

What is primary hemostasis?

Answer 12

Formation of primary platelet plug

Question 13

What is secondary hemostasis?

Answer 13

Fibrin stabilization of primary platelet plug

Question 14

what is budd-chiari

Answer 14

hepatic vein thrombosis that leads to abdominal pain, jaundice, and hepatomegaly