Prototype Drug Unit 8 & 9- Glyburide

Question 1

Classification

Answer 1

Antidiabetic drug

Sulfonylurea

Question 2

What is it used for

Answer 2

Lowering blood glucose levels in patients with type 2 diabetes

Question 3

How does it work?

Answer 3

Stimulates the release of insulin from pancreatic beta cells and increases the sensitivity of peripheral tissues to insulin

Question 4

Adverse effects

Answer 4

Hypoglycemia (too much medications or not eating enough food)
weight gain, hypersensitivity, GI distress, and hepatotoxicity

Question 5

Contraindications

Answer 5

sensitivity to sulfa drugs or thiazide diuretics

Type 1 diabetes (Diabetic coma, DKA)

Question 6

Drug interactions

Answer 6

Alcohol can cause hypo or hyperglycemia
nausea, vomiting, flushing, and palpitations
Anticoagulants, MAOIs, probenecid, sulfonamides, chloramphenicol, osyphenbutazone, phenylbutazone, salicylates, and clofibrate = increases hypoglycemia
Thiazides and rifampin= increased hyperglycemia

Question 7

Herbal/Food interactions

Answer 7

Ginseng, garlic, black cohosh,juniper berries, fenurgreek, coriander, or dandelion root= hypoglycemia

Question 8

Treatment of overdose

Answer 8

Glucose (Dextrose)