Prototype Drug Unit 5 & 7- Carbamazepine

Question 1

Therapeutic classification

Answer 1

Antiepileptic drug

Question 2

Pharmacologic classification

Answer 2

Dibenzazepine, neuronal sodium channel modulator

Question 3

Therapeutic effects and uses

Answer 3

Used for management of partial seizures and complex symptomatology and mixed seizure patterns. Also used for mania associated with bipolar disorder. Also approved for pain with trigeminal neuralgia

Question 4

Mechanism of action

Answer 4

inhibits sodium channels blocking the repeptitive, sustained firing of neurons that is characteristic of epilepsy.

Question 5

Adverse effects

Answer 5

Dizziness, headache, ataxia, fatigue, rash, pruritus, dry mouth, nausea, vomiting, diplopia, abnormal gait

Question 6

Black Box Warning

Answer 6

Aplastic anemia and agranulocytosis have been reported. Serious dermatologic reactions.

Question 7

Contraindications

Answer 7

Hypersensitivity to Tricyclic antidepressants, Intraocular pressure, systemic lupus erythematosus, cardiac disease, hepatic disease, and liver disease, HTN. Be careful for cardiac disease. Do not give if pregnant

Question 8

Drug interactions

Answer 8

Verapamil, erythromycin, ketoconazole, or nefazodone=increased carbamazepine
anticoagulants= decreased hypoprothrombinemic effects

Question 9

Herbal/food interactions

Answer 9

Ginkgo=decrease in entiepileptic effectiveness

Grapefruit juice and St. John’s wort induce CYP enzymes

Question 10

Treatment of overdose

Answer 10

Charcoal and gastric lavage