Prototype Drug Unit 5 & 7- Amantadine Flashcards

1
Q

Therapeutic classification

A

Antiviral for influenza

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2
Q

Pharmacologic classification

A

Viral replication inhibitor

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3
Q

Therapeutic effects and uses

A

Primary use is for influenza

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4
Q

Mechanism of action

A

Not known, but thought to inhibit viral replication by preventing uncoating

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5
Q

Adverse effects

A

Nausea, dizziness, nervousness, difficulty concentrating, insomnia

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6
Q

Contraindications

A

CNS disease, suicidal ideation, psychiatric disorders. Renal impairment, cardiac disease. Should not be abruptly stopped in Parkinson’s disease patients

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7
Q

Drug interactions

A

Alcohol, Anticholinergic drugs, Dopamine antagonists, Trimethoprim-sulfamethoxazle

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8
Q

Treatment of overdose

A

Physostigmine to control CNS symptoms and anticonulsants if necessary. Acidic drugs enhances renal excretion. Antidysrhythmics and antihypertensives may be administered to manage cardiovascular toxicity

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