Prototype Drug Unit 3 & 4- Omeprazole (Prilosec)

Question 1

Therapeutic classification

Answer 1

Antiulcer drug

Question 2

Pharmacologic classification

Answer 2

Proton pump inhibitor

Question 3

Therapeutic effects and uses

Answer 3

Can be used for short or long treatments.

Combined with antibiotics to gets rid of H. pylori

Question 4

Mechanism of action

Answer 4

Reduces acid secretion in the stomach by binding irreversibly to the enzyme H+, K+ -ATPase.

Question 5

Route

Answer 5

PO

Question 6

Absorption

Answer 6

Rapidly absorbed; food does not influence bioavialability

Question 7

Distribution

Answer 7

Bioavailability after oral dosing: 50-60%; crosses the placenta; secreted in breast milk; 95% bound to plasma protein

Question 8

Primary metabolism

Answer 8

Hepaitic

Question 9

Primary excretion

Answer 9

Renal with small amounts in bile

Question 10

Adverse effects

Answer 10

headache, nausea, diarrhea, rash and abdominal pain

Question 11

Contraindications/Precautions

Answer 11

Contraindications: Hypersensitivity, children under the age of 2, lactating or pregnant women

Precautions: Hepatic impairment

Question 12

Drug interactions:

Answer 12

Use with warfarin, carbamazepine, diazepam, and phenytoin can inhibit or delay metabolism.

Question 13

herbal/food interactions

Answer 13

Gingko and St. John’s wort may decrease the plasma concentration of omeprazole

Question 14

Pregnancy category

Answer 14

C