Prototype Drug Unit 3 & 4- Bethanechol (urecholine) Flashcards
What is the therapeutic classification?
Drug to treat urinary retention
What is the pharmacologic classification?
Cholinergic agonist, muscarinic agonist (direct acting)
What are the therapeutic effects and uses?
Stimulates smooth muscle contraction in the digestive and urinalysis tracts. Also used for adynamic lieu’s and gastric atony
What is the mechanism of action?
Interacts directly with muscarinic receptors to cause body responses typical of parasympathetic stimulation
What is the route?
PO (by mouth)
How is it absorbed?
Poorly absorbed by mouth
How is it distributed?
Widely distributed; does not cross the blood-brain barrier
How is it primarily metabolized?
Unknown
How is it primarily excreted?
Renal
What are the adverse effects?
Increased salivation, abdominal cramping, sweating, flushing of the skin, miosis, blurred vision, nausea, and vomiting.
What are the contraindications/precautions?
Don’t give it to people with recent myocardial infarction, severe brachycardia, hypotension, hypertension, peritonitis, epilepsy, and Parkinson’s disease, asthma, or COPD.
Use with caution with people who have bowel obstruction, recent GI surgery, an active ulcer, or an inflammatory disease. Also people who have had urinary obstruction or recent bladder surgery,
What are the drug interactions?
AchE inhibitors and can result on excessive parasympathetic activity. Procainamide, quinidine, atropine, and epinephrine work as antagonists. Ganglionic blockers can cause rapid fall in blood pressure
Pregnancy category
C
Treatment of overdose
Administration of subcutaneous atropine quickly reverses most symptoms
